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The preventive effect of Betelnut polyphenols on high altitude pulmonary edema

Jie fang jun yi xue za zhi, 2021-01, Vol.46 (10), p.961 [Peer Reviewed Journal]

2021] This work is licensed under [CC BY 3.0 Unported - https://creativecommons.org/licenses/by/3.0/ (“the License”). Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License. ;ISSN: 0577-7402 ;DOI: 10.11855/j.issn.0577-7402.2021.10.02

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  • Title:
    The preventive effect of Betelnut polyphenols on high altitude pulmonary edema
  • Author: HUO, Yan ; An-Peng, ZHAO ; Jing-Yan, SONG ; LI, Xue ; Jia-Zhong, LI ; WANG, Rong
  • Subjects: Altitude ; Edema ; Laboratories ; Polyphenols ; Proteins
  • Is Part Of: Jie fang jun yi xue za zhi, 2021-01, Vol.46 (10), p.961
  • Description: Objective　To establish an animal model of high altitude pulmonary edema (HAPE) in the plateau field laboratory, and explore the preventive effect of Betelnut polyphenols on HAPE. Methods　Thirty-six Wistar rats were randomly divided into 6 groups (6 each): control group (4 ml normal saline), HAPE model group (4 ml normal saline), rhodiola group (280 mg/kg Rhodiola capsule) and Betelnut polyphenol group with different doses (400, 800 and 1200 mg/kg Betelnut polyphenol). All animals except those in control group were rushed into the high altitude laboratory at an altitude of 4010 m 3 days after preventive administration and assisted with exhaustive exercise on the running platform, the animals in control group kept in the 940th Hospital of PLA Joint Logistics Support Force. One hour after last administration, abdominal aortic blood, bronchoalveolar lavage fluid (BALF) and lung tissues were collected. The arterial oxygen saturation (SatO2), blood pH, arterial carbon dioxide partial pressure (PaCO2), arterial oxyg
  • Publisher: Beijing: People's Military Medical Press
  • Language: Chinese
  • Identifier: ISSN: 0577-7402
    DOI: 10.11855/j.issn.0577-7402.2021.10.02
  • Source: ProQuest Central
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