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Complementary Sequence-Mediated Exon Circularization
Cell, 2014-09, Vol.159 (1), p.134-147
[Peer Reviewed Journal]
2014 Elsevier Inc. ;Copyright © 2014 Elsevier Inc. All rights reserved. ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2014.09.001 ;PMID: 25242744
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Title:
Complementary Sequence-Mediated Exon Circularization
Author:
Zhang, Xiao-Ou
;
Wang, Hai-Bin
;
Zhang, Yang
;
Lu, Xuhua
;
Chen, Ling-Ling
;
Yang, Li
Subjects:
Alternative Splicing
;
Alu Elements
;
Animals
;
Base Sequence
;
Embryonic Stem Cells - metabolism
;
Evolution, Molecular
;
Exons
;
Genome, Human
;
Humans
;
Introns
;
Mammals - genetics
;
Molecular Sequence Data
;
Nucleic Acid Conformation
;
Sequence Alignment
Is Part Of:
Cell, 2014-09, Vol.159 (1), p.134-147
Description:
Exon circularization has been identified from many loci in mammals, but the detailed mechanism of its biogenesis has remained elusive. By using genome-wide approaches and circular RNA recapitulation, we demonstrate that exon circularization is dependent on flanking intronic complementary sequences. Such sequences and their distribution exhibit rapid evolutionary changes, showing that exon circularization is evolutionarily dynamic. Strikingly, exon circularization efficiency can be regulated by competition between RNA pairing across flanking introns or within individual introns. Importantly, alternative formation of inverted repeated Alu pairs and the competition between them can lead to alternative circularization, resulting in multiple circular RNA transcripts produced from a single gene. Collectively, exon circularization mediated by complementary sequences in human introns and the potential to generate alternative circularization products extend the complexity of mammalian posttranscriptional regulation. [Display omitted] •Exon circularization is dependent on flanking intronic complementary sequences•Exon circularization efficiency is affected by competition of RNA pairing•Alternative RNA pairing and their competition lead to alternative circularization•Both exon circularization and its regulation are evolutionarily dynamic The competition of RNA pairing mediated by flanking intronic complementary sequences regulates exon circularization efficiency and alternative circularization.
Publisher:
United States: Elsevier Inc
Language:
English
Identifier:
ISSN: 0092-8674
EISSN: 1097-4172
DOI: 10.1016/j.cell.2014.09.001
PMID: 25242744
Source:
Cell Press Free Archives
MEDLINE
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