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Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Nature reviews. Molecular cell biology, 2014-01, Vol.15 (1), p.49-63 [Peer Reviewed Journal]

COPYRIGHT 2014 Nature Publishing Group ;COPYRIGHT 2014 Nature Publishing Group ;Copyright Nature Publishing Group Jan 2014 ;ISSN: 1471-0072 ;EISSN: 1471-0080 ;DOI: 10.1038/nrm3722 ;PMID: 24355989

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Title:
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
Author: Czabotar, Peter E ; Lessene, Guillaume ; Strasser, Andreas ; Adams, Jerry M
Subjects: Amino Acid Sequence ; Animals ; Apoptosis ; Apoptosis Regulatory Proteins - chemistry ; Apoptosis Regulatory Proteins - physiology ; Cancer ; Genetic aspects ; Genetic research ; Humans ; Identification and classification ; Models, Molecular ; Molecular Sequence Data ; Molecular Targeted Therapy ; Neoplasms - drug therapy ; Protein Multimerization ; Protein Structure, Secondary ; Proto-Oncogene Proteins c-bcl-2 - chemistry ; Proto-Oncogene Proteins c-bcl-2 - physiology ; Signal Transduction ; Tumor suppressor genes
Is Part Of: Nature reviews. Molecular cell biology, 2014-01, Vol.15 (1), p.49-63
Description: The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell suicide programme that is essential for development, tissue homeostasis and immunity. Too little apoptosis can promote cancer and autoimmune diseases; too much apoptosis can augment ischaemic conditions and drive neurodegeneration. We discuss the biochemical, structural and genetic studies that have clarified how the interplay between members of the BCL-2 family on mitochondria sets the apoptotic threshold. These mechanistic insights into the functions of the BCL-2 family are illuminating the physiological control of apoptosis, the pathological consequences of its dysregulation and the promising search for novel cancer therapies that target the BCL-2 family.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1471-0072
EISSN: 1471-0080
DOI: 10.1038/nrm3722
PMID: 24355989
Source: AUTh Library subscriptions: ProQuest Central
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Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

COPYRIGHT 2014 Nature Publishing Group ;COPYRIGHT 2014 Nature Publishing Group ;Copyright Nature Publishing Group Jan 2014 ;ISSN: 1471-0072 ;EISSN: 1471-0080 ;DOI: 10.1038/nrm3722 ;PMID: 24355989

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