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The Microbiology of Bloodstream Infection: 20-Year Trends from the SENTRY Antimicrobial Surveillance Program

Antimicrobial agents and chemotherapy, 2019-07, Vol.63 (7) [Peer Reviewed Journal]

Copyright © 2019 Diekema et al. ;Copyright © 2019 Diekema et al. 2019 Diekema et al. ;ISSN: 0066-4804 ;EISSN: 1098-6596 ;DOI: 10.1128/aac.00355-19 ;PMID: 31010862

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Title:
The Microbiology of Bloodstream Infection: 20-Year Trends from the SENTRY Antimicrobial Surveillance Program
Author: Diekema, Daniel J ; Hsueh, Po-Ren ; Mendes, Rodrigo E ; Pfaller, Michael A ; Rolston, Kenneth V ; Sader, Helio S ; Jones, Ronald N
Subjects: Acinetobacter baumannii - drug effects ; Acinetobacter baumannii - isolation & purification ; Acinetobacter Infections - epidemiology ; Acinetobacter Infections - microbiology ; Anti-Bacterial Agents - pharmacology ; Bacteremia ; Bacteremia - epidemiology ; Bacteremia - microbiology ; Community-Acquired Infections - epidemiology ; Community-Acquired Infections - microbiology ; Drug Resistance, Bacterial - drug effects ; Enterococcus faecalis - drug effects ; Enterococcus faecalis - isolation & purification ; Epidemiology and Surveillance ; Europe - epidemiology ; Gram-Positive Bacterial Infections - epidemiology ; Gram-Positive Bacterial Infections - microbiology ; Humans ; Klebsiella Infections - epidemiology ; Klebsiella Infections - microbiology ; Klebsiella pneumoniae - drug effects ; Klebsiella pneumoniae - isolation & purification ; Latin America - epidemiology ; Microbial Sensitivity Tests ; Pseudomonas aeruginosa - drug effects ; Pseudomonas aeruginosa - isolation & purification ; Pseudomonas Infections - epidemiology ; Pseudomonas Infections - microbiology ; Staphylococcal Infections - epidemiology ; Staphylococcal Infections - microbiology ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - isolation & purification
Is Part Of: Antimicrobial agents and chemotherapy, 2019-07, Vol.63 (7)
Description: Bloodstream infection (BSI) organisms were consecutively collected from >200 medical centers in 45 nations between 1997 and 2016. Species identification and susceptibility testing followed Clinical and Laboratory Standards Institute broth microdilution methods at a central laboratory. Clinical data and isolates from 264,901 BSI episodes were collected. The most common pathogen overall was (20.7%), followed by (20.5%), (7.7%), (5.3%), and (5.2%). was the most frequently isolated pathogen overall in the 1997-to-2004 period, but was the most common after 2005. Pathogen frequency varied by geographic region, hospital-onset or community-onset status, and patient age. The prevalence of isolates resistant to oxacillin (ORSA) increased until 2005 to 2008 and then declined among hospital-onset and community-acquired BSI in all regions. The prevalence of vancomycin-resistant enterococci (VRE) was stable after 2012 (16.4% overall). Daptomycin resistance among and enterococci (DRE) remained rare (<0.1%). In contrast, the prevalence of multidrug-resistant (MDR) increased from 6.2% in 1997 to 2000 to 15.8% in 2013 to 2016. MDR rates were highest among nonfermentative Gram-negative bacilli (GNB), and colistin was the only agent with predictable activity against complex (97% susceptible). In conclusion, and were the predominant causes of BSI worldwide during this 20-year surveillance period. Important resistant phenotypes among Gram-positive pathogens (MRSA, VRE, or DRE) were stable or declining, whereas the prevalence of MDR-GNB increased continuously during the monitored period. MDR-GNB represent the greatest therapeutic challenge among common bacterial BSI pathogens.
Publisher: United States: American Society for Microbiology
Language: English
Identifier: ISSN: 0066-4804
EISSN: 1098-6596
DOI: 10.1128/aac.00355-19
PMID: 31010862
Source: MEDLINE
PubMed Central

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The Microbiology of Bloodstream Infection: 20-Year Trends from the SENTRY Antimicrobial Surveillance Program

Copyright © 2019 Diekema et al. ;Copyright © 2019 Diekema et al. 2019 Diekema et al. ;ISSN: 0066-4804 ;EISSN: 1098-6596 ;DOI: 10.1128/aac.00355-19 ;PMID: 31010862

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