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EANM practical guidance on uncertainty analysis for molecular radiotherapy absorbed dose calculations

European journal of nuclear medicine and molecular imaging, 2018-12, Vol.45 (13), p.2456-2474 [Peer Reviewed Journal]

The Author(s) 2018 ;European Journal of Nuclear Medicine and Molecular Imaging is a copyright of Springer, (2018). All Rights Reserved. © 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1619-7070 ;EISSN: 1619-7089 ;DOI: 10.1007/s00259-018-4136-7 ;PMID: 30218316

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Title:
EANM practical guidance on uncertainty analysis for molecular radiotherapy absorbed dose calculations
Author: Gear, Jonathan I. ; Cox, Maurice G. ; Gustafsson, Johan ; Gleisner, Katarina Sjögreen ; Murray, Iain ; Glatting, Gerhard ; Konijnenberg, Mark ; Flux, Glenn D.
Subjects: Algorithms ; Annan fysik ; Calibration ; Cardiology ; Chains ; Clinical Medicine ; Dosimeters ; Dosimetry ; Fysik ; Guidelines ; Humans ; Imaging ; Klinisk medicin ; Mathematical models ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Medicine ; Medicine & Public Health ; Natural Sciences ; Naturvetenskap ; Neoplasms - radiotherapy ; Nuclear Medicine ; Oncology ; Orthopedics ; Other Physics Topics ; Physical Sciences ; Practice Guidelines as Topic ; Radiation therapy ; Radiologi och bildbehandling ; Radiology ; Radiology, Nuclear Medicine and Medical Imaging ; Radiopharmaceuticals - administration & dosage ; Radiopharmaceuticals - therapeutic use ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted - methods ; Recovery ; Uncertainty ; Uncertainty analysis ; Yttrium Radioisotopes - administration & dosage ; Yttrium Radioisotopes - therapeutic use
Is Part Of: European journal of nuclear medicine and molecular imaging, 2018-12, Vol.45 (13), p.2456-2474
Description: A framework is proposed for modelling the uncertainty in the measurement processes constituting the dosimetry chain that are involved in internal absorbed dose calculations. The starting point is the basic model for absorbed dose in a site of interest as the product of the cumulated activity and a dose factor. In turn, the cumulated activity is given by the area under a time–activity curve derived from a time sequence of activity values. Each activity value is obtained in terms of a count rate, a calibration factor and a recovery coefficient (a correction for partial volume effects). The method to determine the recovery coefficient and the dose factor, both of which are dependent on the size of the volume of interest (VOI), are described. Consideration is given to propagating estimates of the quantities concerned and their associated uncertainties through the dosimetry chain to obtain an estimate of mean absorbed dose in the VOI and its associated uncertainty. This approach is demonstrated in a clinical example.
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
Language: English
Identifier: ISSN: 1619-7070
EISSN: 1619-7089
DOI: 10.1007/s00259-018-4136-7
PMID: 30218316
Source: MEDLINE
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EANM practical guidance on uncertainty analysis for molecular radiotherapy absorbed dose calculations

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