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Cochlear Stem Cells/Progenitors and Degenerative Hearing Disorders

Current medicinal chemistry, 2007-11, Vol.14 (27), p.2937-2943 [Peer Reviewed Journal]

2008 INIST-CNRS ;Copyright © 2007 Bentham Science Publishers ;ISSN: 0929-8673 ;EISSN: 1875-533X ;DOI: 10.2174/092986707782360051 ;PMID: 18045139

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Title:
Cochlear Stem Cells/Progenitors and Degenerative Hearing Disorders
Author: JIZHEN LIN ; LING FENG ; FUKUDOME, Shinji ; HAMAJIMA, Yuki ; HUANG, Tina ; LEVINE, Samuel
Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Applied cell therapy and gene therapy ; Biological and medical sciences ; Cell Transplantation ; Cochlea - cytology ; Hearing Loss - therapy ; Humans ; Medical sciences ; Stem Cells ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Is Part Of: Current medicinal chemistry, 2007-11, Vol.14 (27), p.2937-2943
Description: Hearing loss (deafness) affects approximately 250 million people globally. The major cause of deafness is loss of hair cells and spiral ganglion neurons due to aging, antibiotic use, noise exposure, and genetic defects. At the present time, there is no effective method for restoration of hearing biologically. Cochlear stem cells/progenitors (CSCs), quiescent in the organ of Corti, are excellent candidates for restoration of cell types in the organ of Corti biologically. However, little is known about the biology of CSCs and developmental cues for CSCs to differentiate into hair cells and neurons at the present time. In this article, we briefly reviewed the isolation of CSCs from the postnatal organ of Corti in mice and their capability to differentiate into hair cells and neurons in vitro under the guidance of a group of growth factors: sonic hedgehog (SHH), epidermal growth factor (EGF), retinoic acid (RA), and brain-derived neurotrophic factor (BDNF), herein termed SERB. The identification of CSCs and their differentiation signals is potentially of clinical importance.
Publisher: Schiphol: Bentham Science Publishers Ltd
Language: English
Identifier: ISSN: 0929-8673
EISSN: 1875-533X
DOI: 10.2174/092986707782360051
PMID: 18045139
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Cochlear Stem Cells/Progenitors and Degenerative Hearing Disorders

2008 INIST-CNRS ;Copyright © 2007 Bentham Science Publishers ;ISSN: 0929-8673 ;EISSN: 1875-533X ;DOI: 10.2174/092986707782360051 ;PMID: 18045139

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