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Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS): Maternal Glycemia and Childhood Glucose Metabolism

Diabetes care, 2019-03, Vol.42 (3), p.381-392 [Peer Reviewed Journal]

2019 by the American Diabetes Association. ;Copyright American Diabetes Association Mar 1, 2019 ;2019 by the American Diabetes Association. 2019 ;ISSN: 0149-5992 ;EISSN: 1935-5548 ;DOI: 10.2337/dc18-2021 ;PMID: 30617141

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Title:
Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS): Maternal Glycemia and Childhood Glucose Metabolism
Author: Scholtens, Denise M ; Kuang, Alan ; Lowe, Lynn P ; Hamilton, Jill ; Lawrence, Jean M ; Lebenthal, Yael ; Brickman, Wendy J ; Clayton, Peter ; Ma, Ronald C ; McCance, David ; Tam, Wing Hung ; Catalano, Patrick M ; Linder, Barbara ; Dyer, Alan R ; Lowe, Jr, William L ; Metzger, Boyd E
Subjects: Adolescent ; Adult ; Blood glucose ; Blood Glucose - metabolism ; Body mass ; Child ; Child of Impaired Parents - statistics & numerical data ; Children ; Cohort Studies ; Diabetes mellitus ; Diabetes Mellitus - blood ; Diabetes Mellitus - epidemiology ; Fasting ; Female ; Follow-Up Studies ; Genetics ; Gestation ; Gestational Diabetes Mellitus: New Evidence for the Continuing Challenge ; Glucose ; Glucose Intolerance - blood ; Glucose Intolerance - epidemiology ; Glucose metabolism ; Glucose tolerance ; Glucose Tolerance Test ; Humans ; Hyperglycemia ; Hyperglycemia - complications ; Hyperglycemia - epidemiology ; Insulin ; Insulin Resistance ; Laboratory testing ; Male ; Maternal & child health ; Metabolism ; Middle Aged ; Prediabetic State - blood ; Prediabetic State - complications ; Prediabetic State - epidemiology ; Pregnancy ; Pregnancy Complications - blood ; Pregnancy Complications - epidemiology ; Pregnancy in Diabetics - blood ; Pregnancy in Diabetics - epidemiology ; Pregnancy Outcome - epidemiology ; Prenatal Exposure Delayed Effects - epidemiology ; Prenatal Exposure Delayed Effects - metabolism ; Research design ; Sensitivity
Is Part Of: Diabetes care, 2019-03, Vol.42 (3), p.381-392
Description: This study examined associations of maternal glycemia during pregnancy with childhood glucose outcomes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort. HAPO was an observational international investigation that established associations of maternal glucose with adverse perinatal outcomes. The HAPO Follow-up Study included 4,832 children ages 10-14 years whose mothers had a 75-g oral glucose tolerance test (OGTT) at ∼28 weeks of gestation. Of these, 4,160 children were evaluated for glucose outcomes. Primary outcomes were child impaired glucose tolerance (IGT) and impaired fasting glucose (IFG). Additional outcomes were glucose-related measures using plasma glucose (PG), A1C, and C-peptide from the child OGTT. Maternal fasting plasma glucose (FPG) was positively associated with child FPG and A1C; maternal 1-h and 2-h PG were positively associated with child fasting, 30 min, 1-h, and 2-h PG, and A1C. Maternal FPG, 1-h, and 2-h PG were inversely associated with insulin sensitivity, whereas 1-h and 2-h PG were inversely associated with disposition index. Maternal FPG, but not 1-h or 2-h PG, was associated with child IFG, and maternal 1-h and 2-h PG, but not FPG, were associated with child IGT. All associations were independent of maternal and child BMI. Across increasing categories of maternal glucose, frequencies of child IFG and IGT, and timed PG measures and A1C were higher, whereas insulin sensitivity and disposition index decreased. Across the maternal glucose spectrum, exposure to higher levels in utero is significantly associated with childhood glucose and insulin resistance independent of maternal and childhood BMI and family history of diabetes.
Publisher: United States: American Diabetes Association
Language: English
Identifier: ISSN: 0149-5992
EISSN: 1935-5548
DOI: 10.2337/dc18-2021
PMID: 30617141
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
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Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS): Maternal Glycemia and Childhood Glucose Metabolism

2019 by the American Diabetes Association. ;Copyright American Diabetes Association Mar 1, 2019 ;2019 by the American Diabetes Association. 2019 ;ISSN: 0149-5992 ;EISSN: 1935-5548 ;DOI: 10.2337/dc18-2021 ;PMID: 30617141

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