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Tissue sodium excess is not hypertonic and reflects extracellular volume expansion

Nature communications, 2020-08, Vol.11 (1), p.4222-4222, Article 4222 [Peer Reviewed Journal]

The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020 ;ISSN: 2041-1723 ;EISSN: 2041-1723 ;DOI: 10.1038/s41467-020-17820-2 ;PMID: 32839436

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  • Title:
    Tissue sodium excess is not hypertonic and reflects extracellular volume expansion
  • Author: Rossitto, Giacomo ; Mary, Sheon ; Chen, Jun Yu ; Boder, Philipp ; Chew, Khai Syuen ; Neves, Karla B. ; Alves, Rheure L. ; Montezano, Augusto C. ; Welsh, Paul ; Petrie, Mark C. ; Graham, Delyth ; Touyz, Rhian M. ; Delles, Christian
  • Subjects: Accumulation ; Aging ; Bioaccumulation ; Cardiovascular diseases ; Edema ; Health risks ; Homeostasis ; Hypertension ; Intracellular ; Risk analysis ; Risk factors ; Sodium ; Tissues
  • Is Part Of: Nature communications, 2020-08, Vol.11 (1), p.4222-4222, Article 4222
  • Description: Abstract Our understanding of Na + homeostasis has recently been reshaped by the notion of skin as a depot for Na + accumulation in multiple cardiovascular diseases and risk factors. The proposed water-independent nature of tissue Na + could induce local pathogenic changes, but lacks firm demonstration. Here, we show that tissue Na + excess upon high Na + intake is a systemic, rather than skin-specific, phenomenon reflecting architectural changes, i.e. a shift in the extracellular-to-intracellular compartments, due to a reduction of the intracellular or accumulation of water-paralleled Na + in the extracellular space. We also demonstrate that this accumulation is unlikely to justify the observed development of experimental hypertension if it were water-independent. Finally, we show that this isotonic skin Na + excess, reflecting subclinical oedema, occurs in hypertensive patients and in association with aging. The implications of our findings, questioning previous assumptions but also reinforcing the importance of tissue Na + excess, are both mechanistic and clinical.
  • Publisher: London: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 2041-1723
    EISSN: 2041-1723
    DOI: 10.1038/s41467-020-17820-2
    PMID: 32839436
  • Source: Open Access: DOAJ Directory of Open Access Journals
    Open Access: PubMed Central
    AUTh Library subscriptions: ProQuest Central
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