skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Next-generation influenza vaccines: opportunities and challenges

Nature reviews. Drug discovery, 2020-04, Vol.19 (4), p.239-252 [Peer Reviewed Journal]

COPYRIGHT 2020 Nature Publishing Group ;COPYRIGHT 2020 Nature Publishing Group ;Springer Nature Limited 2020. ;Springer Nature Limited 2020 ;ISSN: 1474-1776 ;EISSN: 1474-1784 ;DOI: 10.1038/s41573-019-0056-x ;PMID: 32060419

Full text available

Citations Cited by
  • Title:
    Next-generation influenza vaccines: opportunities and challenges
  • Author: Wei, Chih-Jen ; Crank, Michelle C ; Shiver, John ; Graham, Barney S ; Mascola, John R ; Nabel, Gary J
  • Subjects: Antigens ; Forecasts and trends ; Immunological research ; Influenza ; Influenza vaccines ; Pandemics ; Public health ; Review ; Vaccines
  • Is Part Of: Nature reviews. Drug discovery, 2020-04, Vol.19 (4), p.239-252
  • Description: Seasonal influenza vaccines lack efficacy against drifted or pandemic influenza strains. Developing improved vaccines that elicit broader immunity remains a public health priority. Immune responses to current vaccines focus on the haemagglutinin head domain, whereas next-generation vaccines target less variable virus structures, including the haemagglutinin stem. Strategies employed to improve vaccine efficacy involve using structure-based design and nanoparticle display to optimize the antigenicity and immunogenicity of target antigens; increasing the antigen dose; using novel adjuvants; stimulating cellular immunity; and targeting other viral proteins, including neuraminidase, matrix protein 2 or nucleoprotein. Improved understanding of influenza antigen structure and immunobiology is advancing novel vaccine candidates into human trials.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 1474-1776
    EISSN: 1474-1784
    DOI: 10.1038/s41573-019-0056-x
    PMID: 32060419
  • Source: AUTh Library subscriptions: ProQuest Central
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait