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Therapeutic vaccines for cancer: an overview of clinical trials

Nature reviews. Clinical oncology, 2014-09, Vol.11 (9), p.509-524 [Peer Reviewed Journal]

COPYRIGHT 2014 Nature Publishing Group ;COPYRIGHT 2014 Nature Publishing Group ;Copyright Nature Publishing Group Sep 2014 ;Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2014. ;ISSN: 1759-4774 ;ISSN: 1759-4782 ;EISSN: 1759-4782 ;DOI: 10.1038/nrclinonc.2014.111 ;PMID: 25001465 ;CODEN: AJHYE6

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Title:
Therapeutic vaccines for cancer: an overview of clinical trials
Author: Melero, Ignacio ; Gaudernack, Gustav ; Gerritsen, Winald ; Huber, Christoph ; Parmiani, Giorgio ; Scholl, Suzy ; Thatcher, Nicholas ; Wagstaff, John ; Zielinski, Christoph ; Faulkner, Ian ; Mellstedt, Håkan
Subjects: Adjuvants ; Adjuvants, Immunologic - therapeutic use ; Antigens ; Antigens, Neoplasm - immunology ; Breast Neoplasms - drug therapy ; Cancer ; Cancer vaccines ; Cancer Vaccines - therapeutic use ; Carcinoma, Renal Cell - drug therapy ; Clinical trials ; Clinical Trials as Topic ; Colorectal Neoplasms - drug therapy ; Female ; Hematologic Neoplasms - drug therapy ; Humans ; Immune response ; Immunosuppression ; Immunosuppressive agents ; Immunotherapy ; Immunotherapy, Active ; Innovations ; Kidney Neoplasms - drug therapy ; Lung Neoplasms - drug therapy ; Male ; Medicin och hälsovetenskap ; Melanoma - drug therapy ; Methods ; Microenvironments ; Neoplasms - drug therapy ; Observations ; Pancreatic Neoplasms - drug therapy ; Patients ; Prostatic Neoplasms - drug therapy ; Subpopulations ; Testing ; Tumors ; Vaccines
Is Part Of: Nature reviews. Clinical oncology, 2014-09, Vol.11 (9), p.509-524
Description: The therapeutic potential of host-specific and tumour-specific immune responses is well recognized and, after many years, active immunotherapies directed at inducing or augmenting these responses are entering clinical practice. Antitumour immunization is a complex, multi-component task, and the optimal combinations of antigens, adjuvants, delivery vehicles and routes of administration are not yet identified. Active immunotherapy must also address the immunosuppressive and tolerogenic mechanisms deployed by tumours. This Review provides an overview of new results from clinical studies of therapeutic cancer vaccines directed against tumour-associated antigens and discusses their implications for the use of active immunotherapy.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1759-4774
ISSN: 1759-4782
EISSN: 1759-4782
DOI: 10.1038/nrclinonc.2014.111
PMID: 25001465
CODEN: AJHYE6
Source: MEDLINE
ProQuest Central

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Therapeutic vaccines for cancer: an overview of clinical trials

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