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The genetics of panic disorder

Journal of Medical Genetics, 2011-06, Vol.48 (6), p.361-368 [Peer Reviewed Journal]

2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. ;2015 INIST-CNRS ;Copyright: 2011 (c) 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0022-2593 ;EISSN: 1468-6244 ;DOI: 10.1136/jmg.2010.086876 ;PMID: 21493958 ;CODEN: JMDGAE

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Title:
The genetics of panic disorder
Author: Schumacher, Johannes ; Kristensen, Ann Suhl ; Wendland, Jens R ; Nöthen, Markus M ; Mors, Ole ; McMahon, Francis J
Subjects: Adult and adolescent clinical studies ; Age of Onset ; Amygdala - physiopathology ; Anxiety ; anxiety disorders ; Anxiety disorders. Neuroses ; Biological and medical sciences ; Bipolar disorder ; Comorbidity ; Female ; Fundamental and applied biological sciences. Psychology ; General aspects. Genetic counseling ; Genes ; Genetic Association Studies ; Genetic Linkage ; Genetic Predisposition to Disease ; Genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Genome-Wide Association Study ; Genotype ; heritability ; Humans ; Male ; Medical genetics ; Medical sciences ; Molecular and cellular biology ; molecular genetics ; neurosciences ; Panic ; Panic attacks ; Panic disorder ; Panic Disorder - epidemiology ; Panic Disorder - genetics ; Panic Disorder - psychology ; Phenotype ; Prevalence ; psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychotic Disorders - epidemiology ; Psychotic Disorders - genetics ; Psychotic Disorders - psychology ; Quantitative Trait, Heritable ; Respiratory Hypersensitivity - epidemiology ; Respiratory Hypersensitivity - physiopathology ; Respiratory Hypersensitivity - psychology ; Risk Factors ; Social Environment ; Studies ; trait marker ; Twins ; Young Adult
Is Part Of: Journal of Medical Genetics, 2011-06, Vol.48 (6), p.361-368
Description: Panic disorder (PD) is one of the most common anxiety disorders, with a prevalence of 3.4–4.7%. Although PD seems to have no known cause, and its underlying aetiology is not well understood, studies have consistently shown that genetic factors explain about half of the variance. It is likely that most cases of PD have a complex genetic basis. Existing data suggest, however, that the genetic architecture underlying PD is heterogeneous and differs between cases. For example, the degree of genetic complexity, and the pattern of genes involved might differ in familial versus non-familial cases, in early- versus late-onset cases, or when different comorbid conditions, gender and potential intermediate or sub-phenotypes are considered. At the molecular genetic level, linkage and association studies—the latter including traditional candidate gene and recent genome-wide studies—have been used to study PD. Although no robust molecular genetic findings have emerged so far, it is conceivable that the first PD susceptibility genes will be identified in the coming years via the application of modern molecular genetic methods and through multicentre collaborations to bring together combined, large datasets. Such findings could have a major impact on our understanding of the pathophysiology of this disorder, and would provide important opportunities to investigate genotype–phenotype correlations, as well as the interaction between genetic and environmental factors involved in the pathogenesis of PD. Here, the authors summarise the latest genetics findings about PD, and give an overview of anticipated future developments.
Publisher: London: BMJ Publishing Group Ltd
Language: English
Identifier: ISSN: 0022-2593
EISSN: 1468-6244
DOI: 10.1136/jmg.2010.086876
PMID: 21493958
CODEN: JMDGAE
Source: Geneva Foundation Free Medical Journals at publisher websites
Hyper Article en Ligne (HAL) (Open Access)
MEDLINE
Alma/SFX Local Collection
ProQuest Central

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The genetics of panic disorder

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