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Thirty sweet years of GLUT4

The Journal of biological chemistry, 2019-07, Vol.294 (30), p.11369-11381 [Peer Reviewed Journal]

2019 © 2019 Klip et al. ;2019 Klip et al. ;2019 Klip et al. 2019 Klip et al. ;ISSN: 0021-9258 ;EISSN: 1083-351X ;DOI: 10.1074/jbc.REV119.008351 ;PMID: 31175156

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  • Title:
    Thirty sweet years of GLUT4
  • Author: Klip, Amira ; McGraw, Timothy E. ; James, David E.
  • Subjects: Animals ; Biological Transport ; Cloning, Molecular ; Glucose - metabolism ; Glucose Transporter Type 4 - genetics ; Glucose Transporter Type 4 - metabolism ; Humans ; Insulin - metabolism ; Insulin Resistance ; JBC Reviews ; Signal Transduction
  • Is Part Of: The Journal of biological chemistry, 2019-07, Vol.294 (30), p.11369-11381
  • Description: A pivotal metabolic function of insulin is the stimulation of glucose uptake into muscle and adipose tissues. The discovery of the insulin-responsive glucose transporter type 4 (GLUT4) protein in 1988 inspired its molecular cloning in the following year. It also spurred numerous cellular mechanistic studies laying the foundations for how insulin regulates glucose uptake by muscle and fat cells. Here, we reflect on the importance of the GLUT4 discovery and chronicle additional key findings made in the past 30 years. That exocytosis of a multispanning membrane protein regulates cellular glucose transport illuminated a novel adaptation of the secretory pathway, which is to transiently modulate the protein composition of the cellular plasma membrane. GLUT4 controls glucose transport into fat and muscle tissues in response to insulin and also into muscle during exercise. Thus, investigation of regulated GLUT4 trafficking provides a major means by which to map the essential signaling components that transmit the effects of insulin and exercise. Manipulation of the expression of GLUT4 or GLUT4-regulating molecules in mice has revealed the impact of glucose uptake on whole-body metabolism. Remaining gaps in our understanding of GLUT4 function and regulation are highlighted here, along with opportunities for future discoveries and for the development of therapeutic approaches to manage metabolic disease.
  • Publisher: United States: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 0021-9258
    EISSN: 1083-351X
    DOI: 10.1074/jbc.REV119.008351
    PMID: 31175156
  • Source: MEDLINE
    PubMed Central
    Alma/SFX Local Collection
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