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Increase in Alcohol Intake, Reduced Flexibility of Alcohol Drinking, and Evidence of Signs of Alcohol Intoxication in Sardinian Alcohol-Preferring Rats Exposed to Intermittent Access to 20% Alcohol

Alcoholism, clinical and experimental research, 2010-12, Vol.34 (12), p.2147-2154 [Peer Reviewed Journal]

Copyright © 2010 by the Research Society on Alcoholism ;2015 INIST-CNRS ;Copyright © 2010 by the Research Society on Alcoholism. ;ISSN: 0145-6008 ;EISSN: 1530-0277 ;DOI: 10.1111/j.1530-0277.2010.01311.x ;PMID: 20860609 ;CODEN: ACRSDM

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Title:
Increase in Alcohol Intake, Reduced Flexibility of Alcohol Drinking, and Evidence of Signs of Alcohol Intoxication in Sardinian Alcohol-Preferring Rats Exposed to Intermittent Access to 20% Alcohol
Author: Loi, Barbara ; Lobina, Carla ; Maccioni, Paola ; Fantini, Noemi ; Carai, Mauro A. M. ; Gessa, Gian Luigi ; Colombo, Giancarlo
Subjects: "Behavioral" Dependence on Alcohol ; 2-Bottle "Alcohol Versus Water" Choice ; Alcohol Drinking - physiopathology ; Alcohol Drinking - psychology ; Alcoholic beverages ; Alcoholic Intoxication - psychology ; Alcoholism ; Alcoholism - psychology ; Alcoholism and acute alcohol poisoning ; Animals ; Aversion ; Biological and medical sciences ; Choice Behavior - drug effects ; Data processing ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drinking behavior ; Drinking water ; Drug abuse ; Ethanol ; Ethanol - administration & dosage ; Ethanol - pharmacology ; Homecage ; Intermittent Access to Alcohol ; Intoxication ; Male ; Medical sciences ; Quinine ; Quinine - pharmacology ; Rats ; Rats, Inbred Strains ; Reinforcement ; Rotarod Performance Test ; Saccharin ; Saccharin - pharmacology ; Sardinian Alcohol-Preferring (sP) Rats ; Signs of Alcohol Intoxication ; Toxicology
Is Part Of: Alcoholism, clinical and experimental research, 2010-12, Vol.34 (12), p.2147-2154
Description: Background: This study assessed in Sardinian alcohol‐preferring (sP) rats a procedure known to promote alcohol drinking and based on the intermittent (once every other day) access to 2 bottles containing alcohol (20%, v/v) and water, respectively (Wise, 1973). Methods: To this end, sP rats were exposed – under the 2‐bottle choice regimen – to: (i) 10% (v/v) alcohol with continuous access (CA10%; i.e., the procedure under which sP rats had been selectively bred); (ii) 10% (v/v) alcohol with intermittent access (IA10%); (iii) 20% (v/v) alcohol with continuous access (CA20%); (iv) 20% (v/v) alcohol with intermittent access (IA20%; the “Wise” condition) (Experiment 1). Additional experiments assessed the influence of (i) adulteration with quinine of the alcohol solution (Experiment 2) and (ii) concurrent presentation of a saccharin solution (Experiment 3) on alcohol drinking under the CA10% and IA20% conditions. Finally, it was assessed whether alcohol drinking under the CA10% and IA20% conditions resulted in motor incoordination at the Rota‐Rod task, as a possible sign of alcohol intoxication (Experiment 4). Results: Daily alcohol intake markedly escalated in rats exposed to the IA20% condition, averaging 9.0 g/kg (in comparison with the average intake of 6.5 g/kg in the CA10% rat group). CA20% and IA10% rats displayed intermediate values of daily alcohol intake between those of CA10% and IA20% rats. Alcohol intake was virtually abolished by addition of quinine or by concurrent presentation of the saccharin solution in CA10% rats; conversely, alcohol intake in IA20% rats was only partially affected by gustatory aversion or concurrent presentation of an alternative reinforcer. Finally, alcohol intake in IA20%, but not in CA10%, rats resulted in clear motor‐incoordinating effects. Conclusions: These data suggest that the “Wise” procedure is effective in inducing marked increases in alcohol intake in sP rats. These increases are associated with a reduced flexibility of alcohol drinking (suggesting the development of “behavioral” dependence) and produce signs of alcohol intoxication that are not detected when sP rats are exposed to the more conventional CA10% condition.
Publisher: Oxford, UK: Blackwell Publishing Ltd
Language: English
Identifier: ISSN: 0145-6008
EISSN: 1530-0277
DOI: 10.1111/j.1530-0277.2010.01311.x
PMID: 20860609
CODEN: ACRSDM
Source: MEDLINE
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Increase in Alcohol Intake, Reduced Flexibility of Alcohol Drinking, and Evidence of Signs of Alcohol Intoxication in Sardinian Alcohol-Preferring Rats Exposed to Intermittent Access to 20% Alcohol

Copyright © 2010 by the Research Society on Alcoholism ;2015 INIST-CNRS ;Copyright © 2010 by the Research Society on Alcoholism. ;ISSN: 0145-6008 ;EISSN: 1530-0277 ;DOI: 10.1111/j.1530-0277.2010.01311.x ;PMID: 20860609 ;CODEN: ACRSDM

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