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First clinical uterus transplantation trial: a six-month report

Fertility and sterility, 2014-05, Vol.101 (5), p.1228-1236 [Peer Reviewed Journal]

American Society for Reproductive Medicine ;2014 American Society for Reproductive Medicine ;Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. ;ISSN: 0015-0282 ;ISSN: 1556-5653 ;EISSN: 1556-5653 ;DOI: 10.1016/j.fertnstert.2014.02.024 ;PMID: 24582522

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Title:
First clinical uterus transplantation trial: a six-month report
Author: Brännström, Mats, M.D., Ph.D ; Johannesson, Liza, M.D., Ph.D ; Dahm-Kähler, Pernilla, M.D., Ph.D ; Enskog, Anders, M.D., Ph.D ; Mölne, Johan, M.D., Ph.D ; Kvarnström, Niclas, M.D ; Diaz-Garcia, Cesar, M.D ; Hanafy, Ash, M.D ; Lundmark, Cecilia, B.Sc ; Marcickiewicz, Janusz, M.D., Ph.D ; Gäbel, Markus, M.D ; Groth, Klaus, M.D., Ph.D ; Akouri, Randa, M.D., Ph.D ; Eklind, Saskia, M.D., Ph.D ; Holgersson, Jan, M.D., Ph.D ; Tzakis, Andreas, M.D ; Olausson, Michael, M.D., Ph.D
Subjects: ABO Blood-Group System - blood ; ABO Blood-Group System - immunology ; Adult ; Blood Group Incompatibility - blood ; Blood Group Incompatibility - immunology ; Blood Group Incompatibility - prevention & control ; Cohort Studies ; Feasibility Studies ; Female ; Follow-Up Studies ; Graft Rejection - epidemiology ; Graft Rejection - immunology ; Graft Rejection - prevention & control ; human ; Humans ; Immunosuppressive Agents - therapeutic use ; Infertility ; Infertility, Female - drug therapy ; Infertility, Female - epidemiology ; Infertility, Female - surgery ; Internal Medicine ; Kirurgi ; Middle Aged ; Obstetrics and Gynecology ; Obstetrics, Gynecology and Reproductive Medicine ; Prospective Studies ; Reproduktionsmedicin och gynekologi ; Surgery ; Tissue Transplantation - methods ; transplantation ; uterus ; Uterus - immunology ; Uterus - transplantation
Is Part Of: Fertility and sterility, 2014-05, Vol.101 (5), p.1228-1236
Description: Objective To report the 6-month results of the first clinical uterus transplantation (UTx) trial. This type of transplantation may become a treatment of absolute uterine-factor infertility (AUFI). Design Prospective observational study. Setting University hospital. Patient(s) Nine AUFI women and their live uterine donors, the majority being mothers. Intervention(s) Live-donor UTx and low-dose induction immunosuppression. Main Outcome Measure(s) Data from preoperative investigations, surgery and follow-up for 6 months. Result(s) Durations of donor and recipient surgery ranged from 10 to 13 hours and from 4 to 6 hours, respectively. No immediate perioperative complications occurred in any of the recipients. After 6 months, seven uteri remained viable with regular menses. Mild rejection episodes occurred in four of these patients. These rejection episodes were effectively reversed by corticosteroid boluses. The two graft losses were because of acute bilateral thrombotic uterine artery occlusions and persistent intrauterine infection. Conclusion(s) The results demonstrate the feasibility of live-donor UTx with a low-dose immunosuppressive protocol. Clinical trial registration number NCT01844362.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0015-0282
ISSN: 1556-5653
EISSN: 1556-5653
DOI: 10.1016/j.fertnstert.2014.02.024
PMID: 24582522
Source: MEDLINE
Alma/SFX Local Collection

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First clinical uterus transplantation trial: a six-month report

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