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Ambient Air Pollution and Cancer Mortality in the Cancer Prevention Study II

Environmental health perspectives, 2017-08, Vol.125 (8), p.087013 [Peer Reviewed Journal]

COPYRIGHT 2017 National Institute of Environmental Health Sciences ;COPYRIGHT 2017 National Institute of Environmental Health Sciences ;Copyright National Institute of Environmental Health Sciences Aug 2017 ;dc.rights CC0, Turner et al., 2017 info:eu-repo/semantics/openAccess http://creativecommons.org/publicdomain/zero/1.0/ ;ISSN: 0091-6765 ;EISSN: 1552-9924 ;DOI: 10.1289/ehp1249 ;PMID: 28886601

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Title:
Ambient Air Pollution and Cancer Mortality in the Cancer Prevention Study II
Author: Turner, Michelle C ; Krewski, Daniel ; Diver, W Ryan ; Pope, 3rd, C Arden ; Burnett, Richard T ; Jerrett, Michael ; Marshall, Julian D ; Gapstur, Susan M
Subjects: Adult ; Air Pollutants - analysis ; Air pollution ; Air Pollution - statistics & numerical data ; Bladder ; Cancer ; Cancer prevention ; Cancer research ; Carcinogens ; Colorectal carcinoma ; Confidence intervals ; Contaminació ; Càncer ; Death ; Disease prevention ; Ecological effects ; Environmental Exposure - statistics & numerical data ; Epidemiology ; Hazards ; Health aspects ; Health risk assessment ; Humans ; Kidneys ; Lung cancer ; Mortality ; Neoplasms - mortality ; Nitrogen dioxide ; Nitrogen Dioxide - analysis ; Oncology, Experimental ; Outdoor air quality ; Ozone ; Particulate emissions ; Particulate matter ; Particulate Matter - analysis ; Particulates ; Pollutants ; Pollution ; Prevention ; Proportional Hazards Models ; Risk factors ; Statistical analysis ; Statistical models ; Studies ; Time Factors ; United States
Is Part Of: Environmental health perspectives, 2017-08, Vol.125 (8), p.087013
Description: The International Agency for Research on Cancer classified both outdoor air pollution and airborne particulate matter as carcinogenic to humans (Group 1) for lung cancer. There may be associations with cancer at other sites; however, the epidemiological evidence is limited. The aim of this study was to clarify whether ambient air pollution is associated with specific types of cancer other than lung cancer by examining associations of ambient air pollution with nonlung cancer death in the Cancer Prevention Study II (CPS-II). Analysis included 623,048 CPS-II participants who were followed for 22 y (1982-2004). Modeled estimates of particulate matter with aerodynamic diameter <2.5µm (PM ) (1999-2004), nitrogen dioxide (NO ) (2006), and ozone (O ) (2002-2004) concentrations were linked to the participant residence at enrollment. Cox proportional hazards models were used to estimate associations per each fifth percentile-mean increment with cancer mortality at 29 anatomic sites, adjusted for individual and ecological covariates. We observed 43,320 nonlung cancer deaths. PM was significantly positively associated with death from cancers of the kidney {adjusted hazard ratio (HR) per 4.4 μg/m =1.14 [95% confidence interval (CI): 1.03, 1.27]} and bladder [HR=1.13 (95% CI: 1.03, 1.23)]. NO was positively associated with colorectal cancer mortality [HR per 6.5 ppb=1.06 (95% CI: 1.02, 1.10). The results were similar in two-pollutant models including PM and NO and in three-pollutant models with O . We observed no statistically significant positive associations with death from other types of cancer based on results from adjusted models. The results from this large prospective study suggest that ambient air pollution was not associated with death from most nonlung cancers, but associations with kidney, bladder, and colorectal cancer death warrant further investigation. https://doi.org/10.1289/EHP1249.
Publisher: United States: National Institute of Environmental Health Sciences
Language: English
Identifier: ISSN: 0091-6765
EISSN: 1552-9924
DOI: 10.1289/ehp1249
PMID: 28886601
Source: Recercat
US Government Documents
DOAJ Directory of Open Access Journals
AUTh Library subscriptions: ProQuest Central
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PubMed Central

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Ambient Air Pollution and Cancer Mortality in the Cancer Prevention Study II

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