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Hierarchical neural architecture underlying thirst regulation

Nature (London), 2018-03, Vol.555 (7695), p.204-209 [Peer Reviewed Journal]

COPYRIGHT 2018 Nature Publishing Group ;COPYRIGHT 2018 Nature Publishing Group ;Copyright Nature Publishing Group Mar 8, 2018 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature25488 ;PMID: 29489747

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Title:
Hierarchical neural architecture underlying thirst regulation
Author: Augustine, Vineet ; Gokce, Sertan Kutal ; Lee, Sangjun ; Wang, Bo ; Davidson, Thomas J ; Reimann, Frank ; Gribble, Fiona ; Deisseroth, Karl ; Lois, Carlos ; Oka, Yuki
Subjects: Animals ; Appetite - physiology ; Architecture ; Behavior ; Circuits ; Diabetes ; Drinking - physiology ; Drinking behavior ; Drinking water ; External stimuli ; Female ; Fluid dynamics ; Fluids ; GABA ; GABAergic Neurons - metabolism ; Glucagon ; Glucagon-like peptide 1 ; Glucagon-Like Peptide-1 Receptor - metabolism ; Homeostasis ; Ingestion ; Instinct ; Internal water ; Male ; Mice ; Neural circuitry ; Neural networks ; Neural Pathways ; Neurons ; Nitric oxide ; Nitric Oxide Synthase - metabolism ; Nitric-oxide synthase ; Organizational aspects ; Phenotypes ; Physiological aspects ; Population ; Preoptic area (medial) ; Preoptic Area - cytology ; Preoptic Area - physiology ; Rabies ; Rodents ; Satiety ; Satiety Response - physiology ; Subfornical organ ; Subfornical Organ - cytology ; Subfornical Organ - physiology ; Thirst ; Thirst - physiology ; Water balance ; Water-Electrolyte Balance ; γ-Aminobutyric acid
Is Part Of: Nature (London), 2018-03, Vol.555 (7695), p.204-209
Description: Neural circuits for appetites are regulated by both homeostatic perturbations and ingestive behaviour. However, the circuit organization that integrates these internal and external stimuli is unclear. Here we show in mice that excitatory neural populations in the lamina terminalis form a hierarchical circuit architecture to regulate thirst. Among them, nitric oxide synthase-expressing neurons in the median preoptic nucleus (MnPO) are essential for the integration of signals from the thirst-driving neurons of the subfornical organ (SFO). Conversely, a distinct inhibitory circuit, involving MnPO GABAergic neurons that express glucagon-like peptide 1 receptor (GLP1R), is activated immediately upon drinking and monosynaptically inhibits SFO thirst neurons. These responses are induced by the ingestion of fluids but not solids, and are time-locked to the onset and offset of drinking. Furthermore, loss-of-function manipulations of GLP1R-expressing MnPO neurons lead to a polydipsic, overdrinking phenotype. These neurons therefore facilitate rapid satiety of thirst by monitoring real-time fluid ingestion. Our study reveals dynamic thirst circuits that integrate the homeostatic-instinctive requirement for fluids and the consequent drinking behaviour to maintain internal water balance.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0028-0836
EISSN: 1476-4687
DOI: 10.1038/nature25488
PMID: 29489747
Source: ProQuest One Psychology
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Hierarchical neural architecture underlying thirst regulation

COPYRIGHT 2018 Nature Publishing Group ;COPYRIGHT 2018 Nature Publishing Group ;Copyright Nature Publishing Group Mar 8, 2018 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature25488 ;PMID: 29489747

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