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25-Hydroxyvitamin D3 Deficiency Independently Predicts Cognitive Impairment in Patients with Systemic Lupus Erythematosus

PloS one, 2015-12, Vol.10 (12), p.e0144149-e0144149 [Peer Reviewed Journal]

2015 Tay et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2015 Tay et al 2015 Tay et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0144149 ;PMID: 26636681

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Title:
25-Hydroxyvitamin D3 Deficiency Independently Predicts Cognitive Impairment in Patients with Systemic Lupus Erythematosus
Author: Tay, Sen Hee ; Ho, Chung Shun ; Ho, Roger Chun-Man ; Mak, Anselm
Crispin, Jose
Subjects: 25-Hydroxyvitamin D ; Adult ; Age ; Age Factors ; Anxieties ; Anxiety ; Arthritis ; Autoimmune diseases ; Automatic control ; Calcifediol - blood ; Calcifediol - deficiency ; Chromatography ; Chronic conditions ; Cognition Disorders - blood ; Cognition Disorders - etiology ; Cognitive ability ; Cross-Sectional Studies ; Education ; Female ; Health care ; Hospitals ; Humans ; Impairment ; Liquid chromatography ; Lupus ; Lupus Erythematosus, Systemic - blood ; Lupus Erythematosus, Systemic - physiopathology ; Male ; Mass spectrometry ; Mass spectroscopy ; Medical imaging ; Medicine ; Mental depression ; Middle Aged ; Minority & ethnic groups ; Patients ; Psychopathology ; Rheumatology ; Risk factors ; Severity of Illness Index ; Statistical analysis ; Systemic lupus erythematosus ; Vitamin D ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - complications ; Vitamin deficiency
Is Part Of: PloS one, 2015-12, Vol.10 (12), p.e0144149-e0144149
Description: Cognitive dysfunction has been reported in 20-80% of SLE patients. Converging evidence has indicated the importance of vitamin D as a neuroimmunomodulator for cognitive function. In this study, we evaluated the relationship between vitamin D and cognitive dysfunction. Consecutive age- and gender-matched SLE patients and healthy controls (HCs) were administered Automated Neuropsychological Assessment Metrics in this cross-sectional study. The primary outcome was the total throughput score (TTS). Anxiety and depression were measured using the Hospital Anxiety and Depression Scale (HADS). Levels of 25-hydroxyvitamin D [25(OH)D3 and total 25(OH)D] were measured using Liquid Chromatography-Tandem Mass Spectrometry. In total, 61 SLE patients and 61 HCs were studied. SLE patients scored significantly lower than HCs in the TTS (p = 0.004). There were no statistically significant differences in 25(OH)D3 levels, total 25(OH)D levels and total 25(OH)D deficiency between SLE patients and HCs. However, more SLE patients had 25(OH)D3 deficiency compared to HCs [12 (19.7%) versus 2 (3.3%), p = 0.003]. Deficiency of 25(OH)D3 (β = -63.667, SE = 27.456, p = 0.025), but not other vitamin D variables, independently predicted worse TTS after adjusting for age, education, gender, ethnicity, HADS-Total, duration of SLE, SELENA-SLEDAI, SLICC/ACR Damage Index and cumulative steroid dose in SLE patients. Age (β = -4.261, SE = 0.866, p < 0.001) was the only predictor of TTS after adjusting for education, gender, ethnicity, HADS-Total, vitamin D levels or status in HCs. Deficiency of 25(OH)D3, a potentially modifiable risk factor, independently predicted cognitive impairment in SLE patients.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0144149
PMID: 26636681
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Public Library of Science (PLoS)
ProQuest Central
DOAJ Directory of Open Access Journals

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25-Hydroxyvitamin D3 Deficiency Independently Predicts Cognitive Impairment in Patients with Systemic Lupus Erythematosus

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