skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Isolation and NMR Scaling Factors for the Structure Determination of Lobatolide H, a Flexible Sesquiterpene from INeurolaena lobata/I

International journal of molecular sciences, 2023-03, Vol.24 (6) [Peer Reviewed Journal]

COPYRIGHT 2023 MDPI AG ;ISSN: 1422-0067 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms24065841

Full text available

Citations Cited by
  • Title:
    Isolation and NMR Scaling Factors for the Structure Determination of Lobatolide H, a Flexible Sesquiterpene from INeurolaena lobata/I
  • Author: Kovács, Tibor ; Lajter, Ildikó ; Kúsz, Norbert ; Schelz, Zsuzsanna ; Bózsity-Faragó, Noémi ; Borbás, Anikó ; Zupkó, István ; Krupitza, Georg ; Frisch, Richard ; Hohmann, Judit ; Vasas, Andrea ; Mándi, Attila
  • Subjects: Computer software industry
  • Is Part Of: International journal of molecular sciences, 2023-03, Vol.24 (6)
  • Description: A new flexible germacranolide (1, lobatolide H) was isolated from the aerial parts of Neurolaena lobata. The structure elucidation was performed by classical NMR experiments and DFT NMR calculations. Altogether, 80 theoretical level combinations with existing [sup.13]C NMR scaling factors were tested, and the best performing ones were applied on 1. [sup.1]H and [sup.13]C NMR scaling factors were also developed for two combinations utilizing known exomethylene containing derivatives, and the results were complemented by homonuclear coupling constant (J[sub.HH]) and TDDFT-ECD calculations to elucidate the stereochemistry of 1. Lobatolide H possessed remarkable antiproliferative activity against human cervical tumor cell lines with different HPV status (SiHa and C33A), induced cell cycle disturbance and exhibited a substantial antimigratory effect in SiHa cells.
  • Publisher: MDPI AG
  • Language: English
  • Identifier: ISSN: 1422-0067
    EISSN: 1422-0067
    DOI: 10.3390/ijms24065841
  • Source: PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait