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Hyperglycemia Exacerbates Brain Edema and Perihematomal Cell Death After Intracerebral Hemorrhage

Stroke (1970), 2003-09, Vol.34 (9), p.2215-2220 [Peer Reviewed Journal]

2003 American Heart Association, Inc. ;2004 INIST-CNRS ;ISSN: 0039-2499 ;EISSN: 1524-4628 ;DOI: 10.1161/01.STR.0000088060.83709.2C ;PMID: 12907821 ;CODEN: SJCCA7

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Title:
Hyperglycemia Exacerbates Brain Edema and Perihematomal Cell Death After Intracerebral Hemorrhage
Author: Song, Eun-Chol ; Chu, Kon ; Jeong, Sang-Wuk ; Jung, Keun-Hwa ; Kim, Seong-Hoon ; Kim, Manho ; Yoon, Byung-Woo
Subjects: Animals ; Biological and medical sciences ; Blood Glucose ; Body Water - chemistry ; Brain - blood supply ; Brain - pathology ; Brain - physiopathology ; Brain Edema - etiology ; Brain Edema - pathology ; Brain Edema - physiopathology ; Cell Count ; Cell Death ; Cerebral Hemorrhage - complications ; Cerebral Hemorrhage - pathology ; Cerebral Hemorrhage - physiopathology ; Disease Models, Animal ; Disease Progression ; Hematoma, Subdural - etiology ; Hematoma, Subdural - pathology ; Hematoma, Subdural - physiopathology ; Hyperglycemia - complications ; In Situ Nick-End Labeling ; Male ; Medical sciences ; Neurology ; Rats ; Rats, Sprague-Dawley ; Tropical medicine ; Vascular diseases and vascular malformations of the nervous system
Is Part Of: Stroke (1970), 2003-09, Vol.34 (9), p.2215-2220
Description: Background and Purpose— Hyperglycemia has a deleterious effect on brain ischemia. However, the effect of hyperglycemia in intracerebral hemorrhage (ICH) is not well known. We investigated the effect of hyperglycemia on the development of brain edema and perihematomal cell death in ICH.Methods— Hyperglycemia was induced by intraperitoneal injection of streptozotocin (60 mg/kg) in adult Sprague-Dawley male rats. ICH was induced by stereotaxic infusion of 0.23 U of collagenase into the left striatum. Seventy-two hours after ICH, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) staining was performed for perihematomal cell death. We also measured brain water content to evaluate edema formation.Results— The serum glucose level of the hyperglycemic group was 394.0±180.3 mg/dL (n=31), and that of the normoglycemic group was 97.5±27.4 mg/dL (n=31). The size of hemorrhage was similar between groups, without any significant difference (n=8 in each group). The brain water content of hyperglycemic rats (n=17) increased in both lesioned (81.0±0.5%) and nonlesioned hemispheres (78.7±0.6%) compared with the normoglycemic group (n=17; lesioned78.9±0.8%; nonlesioned77.3±1.1%). In the hyperglycemic group, more TUNEL-positive cells were found in the perihematomal regions (n=6).Conclusions— Hyperglycemia caused more profound brain edema and perihematomal cell death in experimental ICH.
Publisher: Hagerstown, MD: American Heart Association, Inc
Language: English
Identifier: ISSN: 0039-2499
EISSN: 1524-4628
DOI: 10.1161/01.STR.0000088060.83709.2C
PMID: 12907821
CODEN: SJCCA7
Source: MEDLINE
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Hyperglycemia Exacerbates Brain Edema and Perihematomal Cell Death After Intracerebral Hemorrhage

2003 American Heart Association, Inc. ;2004 INIST-CNRS ;ISSN: 0039-2499 ;EISSN: 1524-4628 ;DOI: 10.1161/01.STR.0000088060.83709.2C ;PMID: 12907821 ;CODEN: SJCCA7

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