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Thrombin Inhibition by Argatroban Ameliorates Early Brain Injury and Improves Neurological Outcomes After Experimental Subarachnoid Hemorrhage in Rats

Stroke (1970), 2009-04, Vol.40 (4), p.1530-1532 [Peer Reviewed Journal]

2009 INIST-CNRS ;ISSN: 0039-2499 ;EISSN: 1524-4628 ;DOI: 10.1161/STROKEAHA.108.531699 ;PMID: 19228846 ;CODEN: SJCCA7

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Title:
Thrombin Inhibition by Argatroban Ameliorates Early Brain Injury and Improves Neurological Outcomes After Experimental Subarachnoid Hemorrhage in Rats
Author: SUGAWARA, Takashi ; JADHAV, Vikram ; AYER, Robert ; WANQIU CHEN ; SUZUKI, Hidenori ; ZHANG, John H
Subjects: Animals ; Anticoagulants - pharmacology ; Biological and medical sciences ; Blood-Brain Barrier - drug effects ; Brain Edema - blood ; Brain Edema - drug therapy ; Brain Edema - pathology ; Cell Death - drug effects ; Disease Models, Animal ; Male ; Medical sciences ; Motor Activity - drug effects ; Neurology ; Neuropharmacology ; Neuroprotective agent ; Pharmacology. Drug treatments ; Pipecolic Acids - pharmacology ; Rats ; Rats, Sprague-Dawley ; Recovery of Function - drug effects ; Subarachnoid Hemorrhage - blood ; Subarachnoid Hemorrhage - drug therapy ; Subarachnoid Hemorrhage - pathology ; Thrombin - antagonists & inhibitors ; Vascular diseases and vascular malformations of the nervous system
Is Part Of: Stroke (1970), 2009-04, Vol.40 (4), p.1530-1532
Description: We investigated the role of thrombin in early brain injury after subarachnoid hemorrhage (SAH). The standard intravascular perforation model was used to produce experimental SAH in Sprague Dawley rats. Low-dose (0.3 mg/h) and high-dose (0.9 mg/h) argatroban, a direct thrombin inhibitor, were evaluated for effects on brain edema, blood-brain barrier (BBB) disruption, apoptotic cell death, inflammatory marker, and neurological outcomes after SAH. Both doses of argatroban attenuated BBB disruption; however, only high-dose was effective in lowering edema in all brain regions, reducing cell death, and inflammatory marker expression, and improving neurological outcomes. Thrombin inhibition by argatroban improves neurological outcomes and provides neuroprotection against acute events after SAH such as BBB disruption, brain edema, and cell death.
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
Language: English
Identifier: ISSN: 0039-2499
EISSN: 1524-4628
DOI: 10.1161/STROKEAHA.108.531699
PMID: 19228846
CODEN: SJCCA7
Source: MEDLINE
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Thrombin Inhibition by Argatroban Ameliorates Early Brain Injury and Improves Neurological Outcomes After Experimental Subarachnoid Hemorrhage in Rats

2009 INIST-CNRS ;ISSN: 0039-2499 ;EISSN: 1524-4628 ;DOI: 10.1161/STROKEAHA.108.531699 ;PMID: 19228846 ;CODEN: SJCCA7

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