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Evolving concepts of angiogram: fractional flow reserve discordances in 4000 coronary stenoses

European heart journal, 2014-10, Vol.35 (40), p.2831-2838 [Peer Reviewed Journal]

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com. ;ISSN: 0195-668X ;EISSN: 1522-9645 ;DOI: 10.1093/eurheartj/ehu094 ;PMID: 24644308

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Title:
Evolving concepts of angiogram: fractional flow reserve discordances in 4000 coronary stenoses
Author: Toth, Gabor ; Hamilos, Michalis ; Pyxaras, Stylianos ; Mangiacapra, Fabio ; Nelis, Olivier ; De Vroey, Frederic ; Di Serafino, Luigi ; Muller, Olivier ; Van Mieghem, Carlos ; Wyffels, Eric ; Heyndrickx, Guy R ; Bartunek, Jozef ; Vanderheyden, Marc ; Barbato, Emanuele ; Wijns, William ; De Bruyne, Bernard
Subjects: Aged ; Area Under Curve ; Coronary Angiography - methods ; Coronary Angiography - standards ; Coronary Stenosis - diagnostic imaging ; Coronary Stenosis - physiopathology ; Female ; Fractional Flow Reserve, Myocardial - physiology ; Humans ; Isosorbide Dinitrate ; Male ; Prospective Studies ; Sensitivity and Specificity ; Vascular Resistance - physiology ; Vasodilator Agents
Is Part Of: European heart journal, 2014-10, Vol.35 (40), p.2831-2838
Description: The present analysis addresses the potential clinical and physiologic significance of discordance in severity of coronary artery disease between the angiogram and fractional flow reserve (FFR) in a large and unselected patient population. Between September 1999 and December 2011, FFR and percent diameter stenosis (DS) as assessed by quantitative coronary angiography were obtained in 2986 patients (n = 4086 coronary stenoses), in whom at least one stenosis was of intermediate angiographic severity. Fractional flow reserve correlated slightly but significantly with DS [-0.38 (95% CI: -0.41; -0.36); P < 0.001]. The sensitivity, specificity, and diagnostic accuracy of a ≥ 50% DS for predicting FFR ≤ 0.80 were 61% (95% CI: 59; 63), 67% (95% CI: 65; 69), and 0.64 (95% CI: 0.56; 0.72), respectively. In different anatomical settings, sensitivity and specificity showed marked variations between 35 to 74% and 58 to 76%, respectively, resulting in a discordance in 35% of all cases for these thresholds. For an angiographic threshold of 70% DS, the diagnostic performance by the Youden's index decreased from 0.28 to 0.11 for the overall population. The data confirm that one-third of a large patient population shows discordance between angiogram ≥ 50%DS and FFR ≤ 0.8 thresholds of stenosis severity. Left main stenoses are often underestimated by the classical 50% DS cut-off compared with FFR. This discordance offers physiologic insights for future trials. It is hypothesized that the discordance between angiography and FFR is related to technical limitations, such as imprecise luminal border detection by angiography, as well as to physiologic factors, such as variable minimal microvascular resistance.
Publisher: England
Language: English
Identifier: ISSN: 0195-668X
EISSN: 1522-9645
DOI: 10.1093/eurheartj/ehu094
PMID: 24644308
Source: Geneva Foundation Free Medical Journals at publisher websites
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Evolving concepts of angiogram: fractional flow reserve discordances in 4000 coronary stenoses

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com. ;ISSN: 0195-668X ;EISSN: 1522-9645 ;DOI: 10.1093/eurheartj/ehu094 ;PMID: 24644308

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