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The seroincidence of childhood Shigella sonnei infection in Ho Chi Minh City, Vietnam

PLoS neglected tropical diseases, 2023-10, Vol.17 (10), p.e0011728-e0011728 [Peer Reviewed Journal]

Copyright: © 2023 Jones et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ;COPYRIGHT 2023 Public Library of Science ;2023 Jones et al 2023 Jones et al ;ISSN: 1935-2735 ;ISSN: 1935-2727 ;EISSN: 1935-2735 ;DOI: 10.1371/journal.pntd.0011728 ;PMID: 37903147

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Title:
The seroincidence of childhood Shigella sonnei infection in Ho Chi Minh City, Vietnam
Author: Jones, Nick K ; Thu, Trang Nguyen Hoang ; de Alwis, Ruklanthi ; Thompson, Corinne ; Tuyen, Ha Thanh ; Nhu, Tran Do Hoang ; Phat, Voong Vinh ; Trung, Pham Duc ; Lam, Phung Khanh ; Tien, Bui Thi Thuy ; Tuyet, Hoang Thi Diem ; Vi, Lu Lan ; Van Vinh Chau, Nguyen ; Le Thi Quynh, Nhi ; Baker, Stephen
Nascimento, Ana L. T. O.
Subjects: Adolescent ; Adult ; Biology and Life Sciences ; Care and treatment ; Child ; Child, Preschool ; Children ; Diagnosis ; Diseases ; Dysentery, Bacillary - epidemiology ; Earth Sciences ; Ecology and Environmental Sciences ; Humans ; Immunoglobulin G ; Infant ; Medicine and Health Sciences ; O Antigens ; Research and Analysis Methods ; Shigella ; Shigella sonnei ; Shigellosis ; Social Sciences ; Vietnam - epidemiology ; Young Adult
Is Part Of: PLoS neglected tropical diseases, 2023-10, Vol.17 (10), p.e0011728-e0011728
Description: Shigella sonnei is a pathogen of growing global importance as a cause of diarrhoeal illness in childhood, particularly in transitional low-middle income countries (LMICs). Here, we sought to determine the incidence of childhood exposure to S. sonnei infection in a contemporary transitional LMIC population, where it represents the dominant Shigella species. Participants were enrolled between the age of 12-36 months between June and December 2014. Baseline characteristics were obtained through standardized electronic questionnaires, and serum samples were collected at 6-month intervals over two years of follow-up. IgG antibody against S. sonnei O-antigen (anti-O) was measured using an enzyme-linked immunosorbent assay (ELISA). A four-fold increase in ELISA units (EU) with convalescent IgG titre >10.3 EU was taken as evidence of seroconversion between timepoints. A total of 3,498 serum samples were collected from 748 participants; 3,170 from the 634 participants that completed follow-up. Measures of anti-O IgG varied significantly by calendar month (p = 0.03). Estimated S. sonnei seroincidence was 21,451 infections per 100,000 population per year (95% CI 19,307-23,834), with peak incidence occurring at 12-18 months of age. Three baseline factors were independently associated with the likelihood of seroconversion; ever having breastfed (aOR 2.54, CI 1.22-5.26), history of prior hospital admission (aOR 0.57, CI 0.34-0.95), and use of a toilet spray-wash in the household (aOR 0.42, CI 0.20-0.89). Incidence of S. sonnei exposure in Ho Chi Minh City is substantial, with significant reduction in the likelihood of exposure as age increases beyond 2 years.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1935-2735
ISSN: 1935-2727
EISSN: 1935-2735
DOI: 10.1371/journal.pntd.0011728
PMID: 37903147
Source: Public Library of Science (PLoS) Journals Open Access
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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The seroincidence of childhood Shigella sonnei infection in Ho Chi Minh City, Vietnam

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