skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Migraine: multiple processes, complex pathophysiology

The Journal of neuroscience, 2015-04, Vol.35 (17), p.6619-6629 [Peer Reviewed Journal]

Copyright © 2015 the authors 0270-6474/15/356619-11$15.00/0. ;Copyright © 2015 the authors 0270-6474/15/356619-11$15.00/0 2015 ;ISSN: 0270-6474 ;EISSN: 1529-2401 ;DOI: 10.1523/jneurosci.0373-15.2015 ;PMID: 25926442

Full text available

Citations Cited by
  • Title:
    Migraine: multiple processes, complex pathophysiology
  • Author: Burstein, Rami ; Noseda, Rodrigo ; Borsook, David
  • Subjects: Brain - pathology ; Brain - physiopathology ; Disabled Persons ; Disease Focus ; Humans ; Migraine Disorders - genetics ; Migraine Disorders - pathology ; Migraine Disorders - physiopathology ; Migraine Disorders - therapy ; Neurons - physiology
  • Is Part Of: The Journal of neuroscience, 2015-04, Vol.35 (17), p.6619-6629
  • Description: Migraine is a common, multifactorial, disabling, recurrent, hereditary neurovascular headache disorder. It usually strikes sufferers a few times per year in childhood and then progresses to a few times per week in adulthood, particularly in females. Attacks often begin with warning signs (prodromes) and aura (transient focal neurological symptoms) whose origin is thought to involve the hypothalamus, brainstem, and cortex. Once the headache develops, it typically throbs, intensifies with an increase in intracranial pressure, and presents itself in association with nausea, vomiting, and abnormal sensitivity to light, noise, and smell. It can also be accompanied by abnormal skin sensitivity (allodynia) and muscle tenderness. Collectively, the symptoms that accompany migraine from the prodromal stage through the headache phase suggest that multiple neuronal systems function abnormally. As a consequence of the disease itself or its genetic underpinnings, the migraine brain is altered structurally and functionally. These molecular, anatomical, and functional abnormalities provide a neuronal substrate for an extreme sensitivity to fluctuations in homeostasis, a decreased ability to adapt, and the recurrence of headache. Advances in understanding the genetic predisposition to migraine, and the discovery of multiple susceptible gene variants (many of which encode proteins that participate in the regulation of glutamate neurotransmission and proper formation of synaptic plasticity) define the most compelling hypothesis for the generalized neuronal hyperexcitability and the anatomical alterations seen in the migraine brain. Regarding the headache pain itself, attempts to understand its unique qualities point to activation of the trigeminovascular pathway as a prerequisite for explaining why the pain is restricted to the head, often affecting the periorbital area and the eye, and intensifies when intracranial pressure increases.
  • Publisher: United States: Society for Neuroscience
  • Language: English
  • Identifier: ISSN: 0270-6474
    EISSN: 1529-2401
    DOI: 10.1523/jneurosci.0373-15.2015
    PMID: 25926442
  • Source: GFMER Free Medical Journals
    MEDLINE
    PubMed Central
    Alma/SFX Local Collection
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait