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Global Cardiovascular and Renal Outcomes of Reduced GFR

Journal of the American Society of Nephrology, 2017-07, Vol.28 (7), p.2167-2179 [Peer Reviewed Journal]

Copyright © 2017 by the American Society of Nephrology. ;Copyright © 2017 by the American Society of Nephrology 2017 ;ISSN: 1046-6673 ;ISSN: 1533-3450 ;EISSN: 1533-3450 ;DOI: 10.1681/asn.2016050562 ;PMID: 28408440

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Title:
Global Cardiovascular and Renal Outcomes of Reduced GFR
Author: Thomas, Bernadette ; Matsushita, Kunihiro ; Abate, Kalkidan Hassen ; Al-Aly, Ziyad ; Ärnlöv, Johan ; Asayama, Kei ; Atkins, Robert ; Badawi, Alaa ; Ballew, Shoshana H ; Banerjee, Amitava ; Barregård, Lars ; Barrett-Connor, Elizabeth ; Basu, Sanjay ; Bello, Aminu K ; Bensenor, Isabela ; Bergstrom, Jaclyn ; Bikbov, Boris ; Blosser, Christopher ; Brenner, Hermann ; Carrero, Juan-Jesus ; Chadban, Steve ; Cirillo, Massimo ; Cortinovis, Monica ; Courville, Karen ; Dandona, Lalit ; Dandona, Rakhi ; Estep, Kara ; Fernandes, João ; Fischer, Florian ; Fox, Caroline ; Gansevoort, Ron T ; Gona, Philimon N ; Gutierrez, Orlando M ; Hamidi, Samer ; Hanson, Sarah Wulf ; Himmelfarb, Jonathan ; Jassal, Simerjot K ; Jee, Sun Ha ; Jha, Vivekanand ; Jimenez-Corona, Aida ; Jonas, Jost B ; Kengne, Andre Pascal ; Khader, Yousef ; Khang, Young-Ho ; Kim, Yun Jin ; Klein, Barbara ; Klein, Ronald ; Kokubo, Yoshihiro ; Kolte, Dhaval ; Lee, Kristine ; Levey, Andrew S ; Li, Yongmei ; Lotufo, Paulo ; El Razek, Hassan Magdy Abd ; Mendoza, Walter ; Metoki, Hirohito ; Mok, Yejin ; Muraki, Isao ; Muntner, Paul M ; Noda, Hiroyuki ; Ohkubo, Takayoshi ; Ortiz, Alberto ; Perico, Norberto ; Polkinghorne, Kevan ; Al-Radaddi, Rajaa ; Remuzzi, Giuseppe ; Roth, Gregory ; Rothenbacher, Dietrich ; Satoh, Michihiro ; Saum, Kai-Uwe ; Sawhney, Monika ; Schöttker, Ben ; Shankar, Anoop ; Shlipak, Michael ; Silva, Diego Augusto Santos ; Toyoshima, Hideaki ; Ukwaja, Kingsley ; Umesawa, Mitsumasa ; Vollset, Stein Emil ; Warnock, David G ; Werdecker, Andrea ; Yamagishi, Kazumasa ; Yano, Yuichiro ; Yonemoto, Naohiro ; Zaki, Maysaa El Sayed ; Naghavi, Mohsen ; Forouzanfar, Mohammad H ; Murray, Christopher J L ; Coresh, Josef ; Vos, Theo
Subjects: 1974 ; all-cause ; american journal of epidemiology ; cardiovascular disease ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; chronic dialysis ; chronic kidney disease ; Clinical Epidemiology ; Clinical Medicine ; cohorts ; collaborative ; end stage kidney disease ; Epidemiology and outcomes ; ettine.os ; general-population ; Global Health ; Glomerular Filtration Rate ; Health and Welfare ; heart-disease ; Humans ; Hälsa och välfärd ; Kidney - physiopathology ; Kidney Diseases - epidemiology ; Kidney Diseases - etiology ; Klinisk medicin ; maintenance dialysis ; Medicin och hälsovetenskap ; mesoamerican nephropathy ; metaanalysis ; p325 ; population ; risk ; Risk Assessment ; Risk Factors ; Urology & Nephrology ; v99
Is Part Of: Journal of the American Society of Nephrology, 2017-07, Vol.28 (7), p.2167-2179
Description: The burden of premature death and health loss from ESRD is well described. Less is known regarding the burden of cardiovascular disease attributable to reduced GFR. We estimated the prevalence of reduced GFR categories 3, 4, and 5 (not on RRT) for 188 countries at six time points from 1990 to 2013. Relative risks of cardiovascular outcomes by three categories of reduced GFR were calculated by pooled random effects meta-analysis. Results are presented as deaths for outcomes of cardiovascular disease and ESRD and as disability-adjusted life years for outcomes of cardiovascular disease, GFR categories 3, 4, and 5, and ESRD. In 2013, reduced GFR was associated with 4% of deaths worldwide, or 2.2 million deaths (95% uncertainty interval [95% UI], 2.0 to 2.4 million). More than half of these attributable deaths were cardiovascular deaths (1.2 million; 95% UI, 1.1 to 1.4 million), whereas 0.96 million (95% UI, 0.81 to 1.0 million) were ESRD-related deaths. Compared with metabolic risk factors, reduced GFR ranked below high systolic BP, high body mass index, and high fasting plasma glucose, and similarly with high total cholesterol as a risk factor for disability-adjusted life years in both developed and developing world regions. In conclusion, by 2013, cardiovascular deaths attributed to reduced GFR outnumbered ESRD deaths throughout the world. Studies are needed to evaluate the benefit of early detection of CKD and treatment to decrease these deaths.
Publisher: United States: American Society of Nephrology
Language: English
Identifier: ISSN: 1046-6673
ISSN: 1533-3450
EISSN: 1533-3450
DOI: 10.1681/asn.2016050562
PMID: 28408440
Source: Geneva Foundation Free Medical Journals at publisher websites
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Global Cardiovascular and Renal Outcomes of Reduced GFR

Copyright © 2017 by the American Society of Nephrology. ;Copyright © 2017 by the American Society of Nephrology 2017 ;ISSN: 1046-6673 ;ISSN: 1533-3450 ;EISSN: 1533-3450 ;DOI: 10.1681/asn.2016050562 ;PMID: 28408440

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