skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Saliva for assessing creatinine, uric acid, and potassium in nephropathic patients

BMC nephrology, 2019-07, Vol.20 (1), p.242-242, Article 242 [Peer Reviewed Journal]

COPYRIGHT 2019 BioMed Central Ltd. ;The Author(s). 2019 ;ISSN: 1471-2369 ;EISSN: 1471-2369 ;DOI: 10.1186/s12882-019-1437-4 ;PMID: 31272423

Full text available

Citations Cited by
  • Title:
    Saliva for assessing creatinine, uric acid, and potassium in nephropathic patients
  • Author: Bilancio, Giancarlo ; Cavallo, Pierpaolo ; Lombardi, Cinzia ; Guarino, Ermanno ; Cozza, Vincenzo ; Giordano, Francesco ; Palladino, Giuseppe ; Cirillo, Massimo
  • Subjects: Creatinine ; Creatinine tests ; Diagnosis ; Health aspects ; Kidney ; Kidney diseases ; Measurement ; Methods ; Plasma ; Potassium ; Potassium (Nutrient) ; Saliva ; Salivary diagnostics ; Uric acid ; Uric acid tests
  • Is Part Of: BMC nephrology, 2019-07, Vol.20 (1), p.242-242, Article 242
  • Description: Lab tests on saliva could be useful because of low invasivity. Previous reports indicated that creatinine, uric acid, and potassium are measurable in saliva. For these analytes the study investigated methodology of saliva tests and correlations between plasma and saliva levels. The study enrolled 15 healthy volunteers for methodological analyses and 42 nephropathic patients for plasma-saliva correlations (35 non-dialysis and 7 dialysis). Saliva was collected by synthetic swap right after venipuncture for blood withdrawal. Blood and saliva, unless otherwise indicated, were collected early in the morning after overnight fast and lab tests were performed in fresh samples by automated biochemistry (standard). Methodological analyses included blind duplicates, different collection mouth sites, day-to-day variability, different collection times, and freezing-thawing effects. Analyses on plasma-saliva correlations included post-dialysis changes. For saliva lab tests of all analytes, blind duplicates, samples from different mouth sites or of different days were not significantly different but were significantly correlated (differences ≤14.4%; R ≥ 0.620, P ≤ 0.01). For all analytes, mid-morning saliva had lower levels than but correlated with standard saliva (differences ≥15.8%; R ≥ 0.728, P ≤ 0.01). Frozen-thawed saliva had lower levels than fresh saliva for uric acid only (- 17.2%, P < 0.001). Frozen-thawed saliva correlated with fresh saliva for all analytes (R ≥ 0.818, P ≤ 0.001). Saliva and plasma levels differed but correlated with plasma for creatinine (R = 0.874, P < 0.001), uric acid (R = 0.821, P < 0.001) and potassium (R = 0.767, P < 0.001). Post-dialysis changes in saliva paralleled post-dialysis changes in plasma. Saliva levels of creatinine, uric acid, and potassium are measurable and correlated with their plasma levels. Early morning fasting fresh saliva samples are advisable because later collection times or freezing lower the saliva levels of these analytes.
  • Publisher: England: BioMed Central Ltd
  • Language: English
  • Identifier: ISSN: 1471-2369
    EISSN: 1471-2369
    DOI: 10.1186/s12882-019-1437-4
    PMID: 31272423
  • Source: GFMER Free Medical Journals
    PubMed Central
    Springer Nature OA/Free Journals
    ROAD: Directory of Open Access Scholarly Resources
    ProQuest Central
    DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait