Language:

Mitochondrial dynamics regulating chemoresistance in gynecological cancers

Annals of the New York Academy of Sciences, 2015-09, Vol.1350 (1), p.1-16 [Peer Reviewed Journal]

2015 New York Academy of Sciences. ;2015 The New York Academy of Sciences ;ISSN: 0077-8923 ;EISSN: 1749-6632 ;DOI: 10.1111/nyas.12883 ;PMID: 26375862 ;CODEN: ANYAA9

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Mitochondrial dynamics regulating chemoresistance in gynecological cancers
Author: Kong, Bao ; Tsuyoshi, Hideaki ; Orisaka, Makoto ; Shieh, Dar-Bin ; Yoshida, Yoshio ; Tsang, Benjamin K.
Subjects: Animals ; Antineoplastic Agents - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Apoptosis ; Apoptosis - drug effects ; cancer ; CDDP ; chemoresistance ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm ; Female ; Genital Neoplasms, Female - drug therapy ; Genital Neoplasms, Female - metabolism ; Genital Neoplasms, Female - pathology ; Genitalia, Female - drug effects ; Genitalia, Female - metabolism ; Genitalia, Female - pathology ; Humans ; Mitochondrial DNA ; mitochondrial dynamics ; Mitochondrial Dynamics - drug effects ; Models, Biological ; Ovarian cancer
Is Part Of: Annals of the New York Academy of Sciences, 2015-09, Vol.1350 (1), p.1-16
Description: Chemoresistance enables cancer cells to evade apoptotic stimuli and leads to poor clinical prognosis. It arises from dysregulation of signaling factors responsible for inducing cell proliferation and death and for modulating the microenvironment. In gynecologic cancers, p53 is a pivotal determinant of cisplatin sensitivity, while BCL‐2 family members are associated with taxane sensitivity. Mitochondria fusion and fission dynamics are required for many mitochondrial functions and are also involved in mitochondria‐mediated apoptosis, which is closely associated with chemosensitivity. Mitochondrial dynamics are controlled by a number of intracellular proteins, including fusion (Opa1 and mitofusion 1 and 2) and fission proteins (Drp1 and Fis1), which can be proapoptotic or antiapoptotic, depending on the cell types, status, and stimuli from the microenvironment. This paper describes the role of mitochondrial dynamics in the mechanism of chemoresistance and the evidence supporting a significant contribution of a hyperfusion state to chemoresistance in gynecological cancers. Moreover, we discuss our findings showing that enforced fission induces apoptosis of cancer cells and sensitizes them to chemotherapeutic agents. Understanding the regulation of mitochondrial dynamics in chemoresistance may provide insight into new biomarkers that better predict cancer chemosensitivity and may aid the development of effective therapeutic strategies for clinical management of gynecologic cancers.
Publisher: United States: Blackwell Publishing Ltd
Language: English
Identifier: ISSN: 0077-8923
EISSN: 1749-6632
DOI: 10.1111/nyas.12883
PMID: 26375862
CODEN: ANYAA9
Source: MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Mitochondrial dynamics regulating chemoresistance in gynecological cancers

2015 New York Academy of Sciences. ;2015 The New York Academy of Sciences ;ISSN: 0077-8923 ;EISSN: 1749-6632 ;DOI: 10.1111/nyas.12883 ;PMID: 26375862 ;CODEN: ANYAA9

Searching Remote Databases, Please Wait