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Docetaxel Extravasation Causing Significant Delayed Tissue Injury

Gynecologic oncology, 2000-08, Vol.78 (2), p.259-260 [Peer Reviewed Journal]

2000 Academic Press ;2000 INIST-CNRS ;Copyright 2000 Academic Press. ;ISSN: 0090-8258 ;EISSN: 1095-6859 ;DOI: 10.1006/gyno.2000.5873 ;PMID: 10926814 ;CODEN: GYNOA3

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Title:
Docetaxel Extravasation Causing Significant Delayed Tissue Injury
Author: Raley, Janice ; Geisler, John P. ; Buekers, Thomas E. ; Sorosky, Joel I.
Subjects: Aged ; Antineoplastic Agents, Phytogenic - administration & dosage ; Antineoplastic Agents, Phytogenic - adverse effects ; Biological and medical sciences ; Blister - chemically induced ; docetaxel ; Drug toxicity and drugs side effects treatment ; Edema - chemically induced ; Erythema - chemically induced ; extravasation ; Extravasation of Diagnostic and Therapeutic Materials - complications ; Female ; Hand Dermatoses - chemically induced ; Humans ; Medical sciences ; ovarian carcinoma ; Paclitaxel - administration & dosage ; Paclitaxel - adverse effects ; Paclitaxel - analogs & derivatives ; Pharmacology. Drug treatments ; Taxoids ; Toxicity: skin, dermoskeleton ; vesicant
Is Part Of: Gynecologic oncology, 2000-08, Vol.78 (2), p.259-260
Description: Purpose. Docetaxel is a relatively new taxane that has not been associated with significant tissue injury after extravasation. We present a case of a patient who had grade 4 tissue toxicity after extravasation of docetaxel infused through a peripheral intravenous site. Case report. A 71-year-old female was being treated for recurrent ovarian cancer with docetaxel and carboplatin. Shortly after the docetaxel infusion began, she experienced docetaxel extravasation into the dorsum of her left hand. The infusion was halted, and then the administration was continued in a peripheral intravenous site in the other upper extremity. Erythema was noted by the patient on the dorsum of her left hand 6 days after infiltration. The following day, the patient noted severe pain, decreased function, and blistering along with increased erythema. The patient presented to the gynecology oncology clinic 11 days after the extravasation injury occurred. Conservative management was undertaken, and over the next 4 weeks the patient had resolution of the skin changes and full return of function. Conclusion. Docetaxel can cause significant delayed tissue injury if extravasation occurs.
Publisher: San Diego, CA: Elsevier Inc
Language: English
Identifier: ISSN: 0090-8258
EISSN: 1095-6859
DOI: 10.1006/gyno.2000.5873
PMID: 10926814
CODEN: GYNOA3
Source: MEDLINE
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Docetaxel Extravasation Causing Significant Delayed Tissue Injury

2000 Academic Press ;2000 INIST-CNRS ;Copyright 2000 Academic Press. ;ISSN: 0090-8258 ;EISSN: 1095-6859 ;DOI: 10.1006/gyno.2000.5873 ;PMID: 10926814 ;CODEN: GYNOA3

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