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The emergence of lncRNAs in cancer biology
Cancer discovery, 2011-10, Vol.1 (5), p.391-407
ISSN: 2159-8274 ;EISSN: 2159-8290 ;DOI: 10.1158/2159-8290.cd-11-0209 ;PMID: 22096659
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Title:
The emergence of lncRNAs in cancer biology
Author:
Prensner, John R
;
Chinnaiyan, Arul M
Subjects:
Humans
;
Neoplasms - genetics
;
RNA, Untranslated - genetics
Is Part Of:
Cancer discovery, 2011-10, Vol.1 (5), p.391-407
Description:
The discovery of numerous noncoding RNA (ncRNA) transcripts in species from yeast to mammals has dramatically altered our understanding of cell biology, especially the biology of diseases such as cancer. In humans, the identification of abundant long ncRNA (lncRNA) >200 bp has catalyzed their characterization as critical components of cancer biology. Recently, roles for lncRNAs as drivers of tumor suppressive and oncogenic functions have appeared in prevalent cancer types, such as breast and prostate cancer. In this review, we highlight the emerging impact of ncRNAs in cancer research, with a particular focus on the mechanisms and functions of lncRNAs.
Publisher:
United States
Language:
English
Identifier:
ISSN: 2159-8274
EISSN: 2159-8290
DOI: 10.1158/2159-8290.cd-11-0209
PMID: 22096659
Source:
MEDLINE
Alma/SFX Local Collection
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