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Self-Propagating β-Sheet Polypeptide Structures as Prebiotic Informational Molecular Entities: The Amyloid World

Origins of life and evolution of biospheres, 2009-04, Vol.39 (2), p.141-150 [Peer Reviewed Journal]

Springer Science+Business Media B.V. 2009 ;Springer Science+Business Media B.V. 2009. ;ISSN: 0169-6149 ;EISSN: 1573-0875 ;DOI: 10.1007/s11084-009-9165-6 ;PMID: 19301141

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Title:
Self-Propagating β-Sheet Polypeptide Structures as Prebiotic Informational Molecular Entities: The Amyloid World
Author: Maury, C. P. J
Subjects: Aggregates ; Amyloid - chemistry ; Astronomy ; Astrophysics and Astroparticles ; Biochemistry ; Biomedical and Life Sciences ; Earth Sciences ; Epigenetics ; Evolution, Molecular ; Information processing ; Information systems ; Life Sciences ; Models, Molecular ; Observations and Techniques ; Peptides - chemistry ; Prebiotic Chemistry ; Prions - chemistry ; Protein Conformation ; Protein structure ; Protein turnover ; Ribonucleic acid ; RNA ; Transcription
Is Part Of: Origins of life and evolution of biospheres, 2009-04, Vol.39 (2), p.141-150
Description: The idea is advanced that under the extreme earth conditions for ~3.9 billions years ago, protein-based β-sheet molecular structures were the first self-propagating and information-processing biomolecules that evolved. The amyloid structure of these aggregates provided an effective protection against the harsh conditions known to decompose both polyribonucleotides and natively folded polypeptides. In the prebiotic amyloid world, both the replicative and informational functions were carried out by structurally stable β-sheet protein aggregates in a prion-like mode involving templated self-propagation and storage of information in the β-sheet conformation. In this amyloid (protein)-first, hybrid replication-metabolism view, the synthesis of RNA, and the evolvement of an RNA-protein world, were later, but necessary events for further biomolecular evolution to occur. I further argue that in our contemporary DNA[leftright arrow]RNA[rightward arrow]protein world, the primordial β-conformation-based information system is preserved in the form of a cytoplasmic epigenetic memory.
Publisher: Dordrecht: Dordrecht : Springer Netherlands
Language: English;Dutch
Identifier: ISSN: 0169-6149
EISSN: 1573-0875
DOI: 10.1007/s11084-009-9165-6
PMID: 19301141
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Self-Propagating β-Sheet Polypeptide Structures as Prebiotic Informational Molecular Entities: The Amyloid World

Springer Science+Business Media B.V. 2009 ;Springer Science+Business Media B.V. 2009. ;ISSN: 0169-6149 ;EISSN: 1573-0875 ;DOI: 10.1007/s11084-009-9165-6 ;PMID: 19301141

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