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Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response

Frontiers in immunology, 2020-04, Vol.11, p.615-615 [Peer Reviewed Journal]

Copyright © 2020 Wan, Jiang and Hao. ;COPYRIGHT 2020 Frontiers Research Foundation ;Copyright © 2020 Wan, Jiang and Hao. 2020 Wan, Jiang and Hao ;ISSN: 1664-3224 ;EISSN: 1664-3224 ;DOI: 10.3389/fimmu.2020.00615 ;PMID: 32411126

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Title:
Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response
Author: Wan, Dongshan ; Jiang, Wei ; Hao, Junwei
Subjects: Autophagy - physiology ; Biological response modifiers ; Cell Survival ; Cellular Senescence ; cGAMP ; cGAS ; DNA - metabolism ; Humans ; Immunology ; Infections - immunology ; inflammation ; Inflammation - etiology ; Interferon ; Interferon Type I - physiology ; Membrane Proteins - physiology ; Neoplasms - immunology ; Nucleotidyltransferases - physiology ; Signal Transduction - drug effects ; Signal Transduction - physiology ; STING ; type I interferonopathies
Is Part Of: Frontiers in immunology, 2020-04, Vol.11, p.615-615
Description: Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the downstream stimulator of interferon genes (STING) acting as essential immune-surveillance mediators have become hot topics of research. The intrinsic function of the cGAS-STING pathway facilitates type-I interferon (IFN) inflammatory signaling responses and other cellular processes such as autophagy, cell survival, senescence. cGAS-STING pathway interplays with other innate immune pathways, by which it participates in regulating infection, inflammatory disease, and cancer. The therapeutic approaches targeting this pathway show promise for future translation into clinical applications. Here, we present a review of the important previous works and recent advances regarding the cGAS-STING pathway, and provide a comprehensive understanding of the modulatory pattern of the cGAS-STING pathway under multifarious pathologic states.
Publisher: Switzerland: Frontiers Research Foundation
Language: English
Identifier: ISSN: 1664-3224
EISSN: 1664-3224
DOI: 10.3389/fimmu.2020.00615
PMID: 32411126
Source: GFMER Free Medical Journals
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PubMed Central
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DOAJ Directory of Open Access Journals

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Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response

Copyright © 2020 Wan, Jiang and Hao. ;COPYRIGHT 2020 Frontiers Research Foundation ;Copyright © 2020 Wan, Jiang and Hao. 2020 Wan, Jiang and Hao ;ISSN: 1664-3224 ;EISSN: 1664-3224 ;DOI: 10.3389/fimmu.2020.00615 ;PMID: 32411126

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