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Use of ICOS-based cars to enhance antitumor activity and car persistence
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Title:
Use of ICOS-based cars to enhance antitumor activity and car persistence
Author:
Zhao, Yangbing
;
Scholler, John
;
Guedan Carrio, Sonia
;
June, Carl H
Subjects:
AGRICULTURE
;
ANIMAL HUSBANDRY
;
BEER
;
BIOCHEMISTRY
;
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
;
CHEMISTRY
;
COMPOSITIONS THEREOF
;
CULTURE MEDIA
;
ENZYMOLOGY
;
FISHING
;
FORESTRY
;
HUMAN NECESSITIES
;
HUNTING
;
HYGIENE
;
MEDICAL OR VETERINARY SCIENCE
;
METALLURGY
;
MICROBIOLOGY
;
MICROORGANISMS OR ENZYMES
;
MUTATION OR GENETIC ENGINEERING
;
ORGANIC CHEMISTRY
;
PEPTIDES
;
PEST REPELLANTS OR ATTRACTANTS
;
PLANT GROWTH REGULATORS
;
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
;
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
;
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
;
SPIRITS
;
TRAPPING
;
VINEGAR
;
WINE
Description:
The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a genetically modified Th17 cell to express a CAR having an antigen binding domain, a transmembrane domain, and an ICOS intracellular signaling domain.
Creation Date:
2024
Language:
English
Source:
esp@cenet
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