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Plasma Adiponectin Is an Independent Predictor of Type 2 Diabetes in Asian Indians

Diabetes care, 2003-12, Vol.26 (12), p.3226-3229 [Peer Reviewed Journal]

2004 INIST-CNRS ;Copyright American Diabetes Association Dec 2003 ;ISSN: 0149-5992 ;EISSN: 1935-5548 ;DOI: 10.2337/diacare.26.12.3226 ;PMID: 14633806 ;CODEN: DICAD2

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  • Title:
    Plasma Adiponectin Is an Independent Predictor of Type 2 Diabetes in Asian Indians
  • Author: SNEIHALATHA, Chamukuttan ; MUKESH, Bheekamchand ; SIMON, Mary ; VISWANATHAN, Vijay ; HAFFNER, Steven M ; RAMACHANDRAN, Ambady
  • Subjects: Adiponectin ; Adult ; Biological and medical sciences ; Blood Glucose - metabolism ; Body Constitution ; Cohort Studies ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; European Continental Ancestry Group ; Female ; Follow-Up Studies ; Humans ; India - ethnology ; Intercellular Signaling Peptides and Proteins ; Male ; Medical sciences ; Metabolism ; Middle Aged ; Minority & ethnic groups ; Plasma ; Predictive Value of Tests ; Proteins - metabolism ; Time Factors
  • Is Part Of: Diabetes care, 2003-12, Vol.26 (12), p.3226-3229
  • Description: Plasma Adiponectin Is an Independent Predictor of Type 2 Diabetes in Asian Indians Chamukuttan Snehalatha , MSC, DSC 1 , Bheekamchand Mukesh , MBBS 1 , Mary Simon , BSC 1 , Vijay Viswanathan , MD, PHD 1 , Steven M. Haffner , MD 2 and Ambady Ramachandran , MD, PHD, FRCP 1 1 Diabetes Research Centre, M.V. Hospital for Diabetes, WHO Collaborating Centre for Research, Education & Training in Diabetes, Royapuram, Chennai, India 2 Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center of San Antonio, San Antonio, Texas Address correspondence and reprint requests to Prof. A. Ramachandran, Director, Diabetes Research Centre, M.V. Hospital for Diabetes & WHO Collaborating Centre for Research, Education & Training in Diabetes, 4 Main Rd., Royapuram, Chennai 600 013, India. E-mail: ramachandran{at}vsnl.com Abstract OBJECTIVE —Adiponectin, secreted by fat cells, has regulatory functions on energy metabolism. Its low levels are predictive of future development of diabetes. Because no studies on the regulatory role of adiponectin in glucose homeostasis in Asian Indians exist, this analysis was performed to determine the prospective association of adiponectin and diabetes in subjects with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS —Baseline values of plasma adiponectin, results of anthropometry, fasting and 2-h plasma glucose levels, HbA 1c , results of lipid profile, and insulin resistance were analyzed in 91 subjects with IGT (53 men and 38 women) in a primary prevention study. Reassessment of glucose tolerance was performed during 1-year review. The predictive nature of adiponectin for development of diabetes was assessed using univariate and multiple logistic regression analyses. A control group comprising healthy, normoglycemic individuals was used for comparison. RESULTS —At follow-up, diabetes had developed in 25 of the 91 study subjects. The mean baseline adiponectin level was lower in the diabetic subjects than in the nondiabetic subjects (11.3 ± 5.5 vs. 16.7 ± 7.6 μg/ml, P = 0.0017). Low adiponectin level was a strong predictor of future development of diabetes, and HbA 1c also showed a positive predictive association. Women had higher adiponectin levels (16.4 ± 6.1 μg/ml) than men (13.9 ± 7.6 μg/ml) ( P = 0.035). CONCLUSIONS —In Asian Indians, low plasma adiponectin level was predictive of future development of diabetes. IGT, impaired glucose tolerance NGT, normal glucose tolerance OGTT, oral glucose tolerance test Footnotes A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances. Accepted August 26, 2003. Received June 5, 2003. DIABETES CARE
  • Publisher: Alexandria, VA: American Diabetes Association
  • Language: English
  • Identifier: ISSN: 0149-5992
    EISSN: 1935-5548
    DOI: 10.2337/diacare.26.12.3226
    PMID: 14633806
    CODEN: DICAD2
  • Source: MEDLINE
    Alma/SFX Local Collection
    ProQuest Central
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