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Correlation of clinical, laboratory, and short‐term outcomes of immunocompromised and immunocompetent COVID‐19 patients with semi‐quantitative chest CT score findings: A case‐control study

Immunity, Inflammation and Disease, 2024-04, Vol.12 (4), p.e1239-n/a [Peer Reviewed Journal]

2024 The Authors. published by John Wiley & Sons Ltd. ;2024 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. ;2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 2050-4527 ;EISSN: 2050-4527 ;DOI: 10.1002/iid3.1239 ;PMID: 38577996

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  • Title:
    Correlation of clinical, laboratory, and short‐term outcomes of immunocompromised and immunocompetent COVID‐19 patients with semi‐quantitative chest CT score findings: A case‐control study
  • Author: Ghadery, Abdolkarim Haji ; Abbasian, Ladan ; Jafari, Fatemeh ; Yazdi, Niloofar Ayoobi ; Ahmadinejad, Zahra
  • Subjects: Acquired immune deficiency syndrome ; AIDS ; Case-Control Studies ; case‐control ; Chemotherapy ; chest CT score ; Coronaviruses ; COVID-19 ; Dyspnea ; Hemoptysis ; HIV ; Human immunodeficiency virus ; Humans ; Immune system ; Immunocompetence ; immunocompetent ; immunocompromised ; Immunocompromised Host ; Infections ; Laboratories ; Lungs ; Medical imaging ; Pandemics ; Patients ; Statistical analysis ; Steroids ; Tomography, X-Ray Computed ; Transplants & implants ; Variables
  • Is Part Of: Immunity, Inflammation and Disease, 2024-04, Vol.12 (4), p.e1239-n/a
  • Description: Background As the effects of immunosuppression are not still clear on COVID‐19 patients, we conducted this study to identify clinical and laboratory findings associated with pulmonary involvement in both immunocompromised and immunocompetent patients. Methods A case‐control of 107 immunocompromised and 107 immunocompetent COVID‐19 patients matched for age and sex with either positive RT‐PCR or clinical‐radiological findings suggestive of COVID‐19 enrolled in the study. Their initial clinical features, laboratory findings, chest CT scans, and short‐term outcomes (hospitalization time and intensive care unit [ICU] admission) were recorded. In addition, pulmonary involvement was assessed with the semi‐quantitative scoring system (0−25). Results Pulmonary involvement was significantly lower in immunocompromised patients in contrast to immunocompetent patients, especially in RLL (p = 0.001), LUL (p = 0.023), and both central and peripheral (p = 0.002), and peribronchovascular (p = 0.004) sites of lungs. Patchy (p < 0.001), wedged (p = 0.002), confluent (p = 0.002) lesions, and ground glass with consolidation pattern (p < 0.001) were significantly higher among immunocompetent patients. Initial signs and symptoms of immunocompromised patients including dyspnea (p = 0.008) and hemoptysis (p = 0.036), respiratory rate of over 25 (p < 0.001), and spo2 of below 93% (p = 0.01) were associated with higher pulmonary involvement. Total chest CT score was also associated with longer hospitalization (p = 0.016) and ICU admission (p = 0.04) among immunocompromised patients. Conclusions Pulmonary involvement score was not significantly different among immunocompromised and immunocompetent patients. Initial clinical findings (dyspnea, hemoptysis, higher RR, and lower Spo2) of immunocompromised patients could better predict pulmonary involvement than laboratory findings.
  • Publisher: England: John Wiley & Sons, Inc
  • Language: English
  • Identifier: ISSN: 2050-4527
    EISSN: 2050-4527
    DOI: 10.1002/iid3.1239
    PMID: 38577996
  • Source: MEDLINE
    PubMed Central
    Wiley Blackwell Open Access Titles
    Coronavirus Research Database
    ProQuest Central
    DOAJ Directory of Open Access Journals
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