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Genetic analysis of over half a million people characterises C-reactive protein loci

Nature communications, 2022-04, Vol.13 (1), p.2198-2198, Article 2198 [Peer Reviewed Journal]

2022. The Author(s). ;The Author(s) 2022. corrected publication 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2022, corrected publication 2022 ;ISSN: 2041-1723 ;EISSN: 2041-1723 ;DOI: 10.1038/s41467-022-29650-5 ;PMID: 35459240

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Title:
Genetic analysis of over half a million people characterises C-reactive protein loci
Author: Said, Saredo ; Pazoki, Raha ; Karhunen, Ville ; Võsa, Urmo ; Ligthart, Symen ; Bodinier, Barbara ; Koskeridis, Fotios ; Welsh, Paul ; Alizadeh, Behrooz Z ; Chasman, Daniel I ; Sattar, Naveed ; Chadeau-Hyam, Marc ; Evangelou, Evangelos ; Jarvelin, Marjo-Riitta ; Elliott, Paul ; Tzoulaki, Ioanna ; Dehghan, Abbas
Subjects: Aging ; Airway management ; Biomarkers ; C-reactive protein ; C-Reactive Protein - genetics ; C-Reactive Protein - metabolism ; Chronic illnesses ; Clinical outcomes ; Diseases ; Epidemiology ; Gene expression ; Gene loci ; Genetic analysis ; Genetic Loci ; Genome-wide association studies ; Genome-Wide Association Study ; Humans ; Inflammation ; Inflammation - genetics ; Loci ; Male ; Mendelian Randomization Analysis ; Mental disorders ; Phenomics ; Polymorphism, Single Nucleotide ; Prostate cancer ; Proteins ; Schizophrenia ; Tissue analysis
Is Part Of: Nature communications, 2022-04, Vol.13 (1), p.2198-2198, Article 2198
Description: Chronic low-grade inflammation is linked to a multitude of chronic diseases. We report the largest genome-wide association study (GWAS) on C-reactive protein (CRP), a marker of systemic inflammation, in UK Biobank participants (N = 427,367, European descent) and the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium (total N = 575,531 European descent). We identify 266 independent loci, of which 211 are not previously reported. Gene-set analysis highlighted 42 gene sets associated with CRP levels (p ≤ 3.2 ×10 ) and tissue expression analysis indicated a strong association of CRP related genes with liver and whole blood gene expression. Phenome-wide association study identified 27 clinical outcomes associated with genetically determined CRP and subsequent Mendelian randomisation analyses supported a causal association with schizophrenia, chronic airway obstruction and prostate cancer. Our findings identified genetic loci and functional properties of chronic low-grade inflammation and provided evidence for causal associations with a range of diseases.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2041-1723
EISSN: 2041-1723
DOI: 10.1038/s41467-022-29650-5
PMID: 35459240
Source: AUTh Library subscriptions: ProQuest Central
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Genetic analysis of over half a million people characterises C-reactive protein loci

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