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Ratiometric Near-Infrared Fluorescence Liposome Nanoprobe for H[sub.2]S Detection In Vivo

Molecules (Basel, Switzerland), 2023-02, Vol.28 (4) [Peer Reviewed Journal]

COPYRIGHT 2023 MDPI AG ;ISSN: 1420-3049 ;EISSN: 1420-3049 ;DOI: 10.3390/molecules28041898

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  • Title:
    Ratiometric Near-Infrared Fluorescence Liposome Nanoprobe for H[sub.2]S Detection In Vivo
  • Author: Wu, Luyan ; Liu, Yili ; Zhang, Junya ; Miao, Yinxing ; An, Ruibing
  • Subjects: Chemical properties ; Fluorescence
  • Is Part Of: Molecules (Basel, Switzerland), 2023-02, Vol.28 (4)
  • Description: Accurate detection of H[sub.2]S is crucial to understanding the occurrence and development of H[sub.2]S-related diseases. However, the accurate and sensitive detection of H[sub.2]S in vivo still faces great challenges due to the characteristics of H[sub.2]S diffusion and short half-life. Herein, we report a H[sub.2]S-activatable ratiometric near-infrared (NIR) fluorescence liposome nanoprobe HS-CG by the thin-film hydration method. HS-CG shows “always on” fluorescence signal at 816 nm and low fluorescence signal at 728 nm; the NIR fluorescence ratio between 728 and 816 nm (F[sub.728]/F[sub.816]) is low. Upon reaction with H[sub.2]S, the fluorescence at 728 nm could be more rapidly turned on due to strong electrostatic interaction between enriched HS[sup.−] and positively charged 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC) doped in the liposome nanoprobe HS-CG, resulting in a large enhancement of F[sub.728]/F[sub.816], which allows for sensitive visualization of the tumor H[sub.2]S levels in vivo. This study demonstrates that this strategy of electrostatic adsorption between HS[sup.−] and positively charged molecules provides a new way to enhance the reaction rate of the probe and H[sub.2]S, thus serving as an effective platform for improving the sensitivity of imaging.
  • Publisher: MDPI AG
  • Language: English
  • Identifier: ISSN: 1420-3049
    EISSN: 1420-3049
    DOI: 10.3390/molecules28041898
  • Source: Open Access: PubMed Central
    Geneva Foundation Free Medical Journals at publisher websites
    Alma/SFX Local Collection
    ProQuest Central
    DOAJ Directory of Open Access Journals
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