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Cardiovascular Events in People With Type 2 Diabetes: Performance of Framingham, UKPDS, and ADVANCE Risk Equations

Acta medica Iranica, 2021, Vol.59 (10), p.610-616 [Peer Reviewed Journal]

2021. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 0044-6025 ;EISSN: 1735-9694 ;DOI: 10.18502/acta.v59i10.7768

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  • Title:
    Cardiovascular Events in People With Type 2 Diabetes: Performance of Framingham, UKPDS, and ADVANCE Risk Equations
  • Author: Yaghoubvand, Elaheh ; Aghili, Rokhsareh ; Khajavi, Alireza ; Khamseh, Mohammad Ebrahim
  • Subjects: advance ; Blood pressure ; Calibration ; Cardiovascular disease ; cvd ; Diabetes ; Endocrinology ; event ; framingham ; Heart attacks ; Hyperglycemia ; Mathematical functions ; Medical records ; Metabolism ; Population ; risk ; Stroke ; ukpds ; Validation studies
  • Is Part Of: Acta medica Iranica, 2021, Vol.59 (10), p.610-616
  • Description: The aim of this study was to assess the performance of the Framingham, UK Prospective Diabetes Study (UKPDS), and the Action in Diabetes and Vascular disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) risk equations in the prediction of 4-year cardiovascular disease CVD) in Iranian people with type 2 diabetes. The 4-year risks of CVD were estimated using the three equations in a community of 557 patients with type 2 diabetes and free of CVD at baseline. A trained physician evaluated all of the participants regarding the occurrence of CVD events during follow-up. CVD was defined as major events including fatal/non-fatal myocardial infarction as well as fatal/non-fatal stroke, minor events including treated coronary heart disease (CHD), and established peripheral arterial disease (PAD). During four years of follow-up, 64 CVD events were observed (66% minor CVD events). Despite having a good calibration (estimated to observed ratio ranging from 91.37 to 98.2 percent, Hosmer–Lemeshow χ2 (HLχ2) values <15), both general (Framingham) and diabetes-specific (UKPDS and ADVANCE) equations did not have adequate discriminative ability (Area Under the Curve (AUC) ranging from 0.48 to 0.56). Framingham, UKPDS, and ADVANCE risk equations, regardless of being general or diabetes-specific, could not precisely predict 4-year risk of CVD in Iranian individuals with type 2 diabetes.
  • Publisher: Tehran: Tehran University of Medical Sciences
  • Language: English;French
  • Identifier: ISSN: 0044-6025
    EISSN: 1735-9694
    DOI: 10.18502/acta.v59i10.7768
  • Source: GFMER Free Medical Journals
    ProQuest Central
    DOAJ Directory of Open Access Journals
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