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Microbiological and Clinicoepidemiological Profile of a Series of Patients with Infective Endocarditis at a Center in Eastern Nepal

The Canadian journal of infectious diseases & medical microbiology, 2021, Vol.2021, p.1-8 [Peer Reviewed Journal]

Copyright © 2021 Sohani Bajracharya et al. ;Copyright © 2021 Sohani Bajracharya et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 ;Copyright © 2021 Sohani Bajracharya et al. 2021 ;ISSN: 1712-9532 ;EISSN: 1918-1493 ;DOI: 10.1155/2021/9980465 ;PMID: 34336067

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Title:
Microbiological and Clinicoepidemiological Profile of a Series of Patients with Infective Endocarditis at a Center in Eastern Nepal
Author: Bajracharya, Sohani ; Khanal, Basudha ; Siwakoti, Shraddha ; Singh, Rupa Rajbhandari ; Sharma, Sanjib Kumar
Bautista, Marcos Christian ; Marcos Christian Bautista
Subjects: Antibiotics ; Antiinfectives and antibacterials ; Aorta ; Aortic valve ; Blood ; Blood culture ; Cardiovascular disease ; Cardiovascular diseases ; Congestive heart failure ; Coronary artery disease ; Culture ; Drug abuse ; Endocarditis ; Epidemiology ; Etiology ; Heart ; Heart diseases ; Heart valves ; Hemodialysis ; Laboratories ; Microorganisms ; Patients ; Pediatrics ; Prostheses ; Pseudomonas aeruginosa ; Rheumatic heart disease ; Staphylococcus aureus ; Staphylococcus infections ; Statistical analysis ; Substance abuse treatment ; Ultrasonic imaging ; Vegetation
Is Part Of: The Canadian journal of infectious diseases & medical microbiology, 2021, Vol.2021, p.1-8
Description: Background. The microbiological and clinicoepidemiological profile of infective endocarditis (IE) has undergone significant change over time. The pattern of IE studied at local level provides broader vision in understanding the current scenario of this disease. This study aimed to depict the overall picture of IE and its changing profile by evaluating the microbiological and clinicoepidemiological features in the context of a tertiary care center of eastern Nepal. Methods. The descriptive study was conducted from September 2017 to August 2018 among IE patients presenting to B. P. Koirala Institute of Health Sciences, Nepal. Detailed history and clinical manifestations of patients were noted. Microorganisms isolated from the blood culture were processed for identification by standard microbiological methods, and susceptibility testings were done. Each patient was assessed daily during hospital stay. Results. Ten definite and 7 possible endocarditis cases were studied. The mean age was 41.4 ± 15.85 (17–70) years with predominance of male (4.7 : 1). Rheumatic heart disease (41.1%) was the most common underlying heart disease observed followed by injection drug user endocarditis (23.5%). All the cases had native valve endocarditis. Aortic valve was the most common valve involved (35.3%) followed by mitral, tricuspid, and pulmonary valves. Blood culture positivity was 53%. Staphylococcus aureus was the major causative agent responsible for 23.5% of the cases followed by Enterococcus faecium, Enterococcus faecalis, and Pseudomonas aeruginosa. Mortality of 2 cases (11.8%) was associated with S. aureus and P. aeruginosa. Majority of patients developed acute kidney injury (35.3%) and congestive cardiac failure (23.5%). Conclusion. IE patients in our center exhibited differences from the west in terms of age at presentation and predisposing factors but held similarity in terms of commonly isolated microorganisms. The changing patterns of IE, etiological agents, and their antimicrobial susceptibility observed in this study may be helpful for clinicians in formulating a new empirical antibiotic treatment protocol.
Publisher: Oakville: Hindawi
Language: English;French
Identifier: ISSN: 1712-9532
EISSN: 1918-1493
DOI: 10.1155/2021/9980465
PMID: 34336067
Source: AUTh Library subscriptions: ProQuest Central
GFMER Free Medical Journals
PubMed Central
DOAJ Directory of Open Access Journals

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Microbiological and Clinicoepidemiological Profile of a Series of Patients with Infective Endocarditis at a Center in Eastern Nepal

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