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A New β-Carboline Alkaloid From the Aerial Part of Hedyotis capitellata
Natural product communications, 2021-10, Vol.16 (10), p.1934578
[Peer Reviewed Journal]
The Author(s) 2021 ;ISSN: 1934-578X ;EISSN: 1555-9475 ;DOI: 10.1177/1934578X211047705
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Title:
A New β-Carboline Alkaloid From the Aerial Part of Hedyotis capitellata
Author:
Huyen, Le Thi
;
Thu Hau, Nguyen Thi
;
Vu, Hoang Son
;
Lan Huyen, Nguyen Thi
;
Huu Tai, Bui
;
Nhiem, Nguyen Xuan
;
Van Kiem, Phan
Is Part Of:
Natural product communications, 2021-10, Vol.16 (10), p.1934578
Description:
A new β-carboline alkaloid, 10-hydroxy-capitelline (1) together with three known anthraquinones, hedanthroside B (2), hedanthroside C (3), and rubiadin (4) were isolated from the aerial part methanol extract of Hedyotis capitellata. Their structures were established by spectroscopic data (one-dimensional, two-dimensional nuclear magnetic resonance (1D, 2D-NMR) and high-resolution-electrospray ionization-mass spectrometry, HR-ESI-MS) and comparison with those reported in the literature. The anti-inflammatory activity of the isolated compounds is evaluated by their inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. At a concentration of 20 µM, compounds 1 to 4 showed weak inhibitory effects on NO production with inhibitory values ranging from 1.2% to 23.9% compared to a value of 74.5% for the positive control compound, NG-monomethyl-L-arginine (L-NMMA).
Publisher:
Los Angeles, CA: SAGE Publications
Language:
English
Identifier:
ISSN: 1934-578X
EISSN: 1555-9475
DOI: 10.1177/1934578X211047705
Source:
SAGE Open Access Journals
DOAJ Directory of Open Access Journals
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