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Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease

The New England journal of medicine, 2016-12, Vol.375 (24), p.2349-2358 [Peer Reviewed Journal]

Copyright © 2016 Massachusetts Medical Society. All rights reserved. ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1605086 ;PMID: 27959714

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Title:
Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease
Author: Khera, Amit V ; Emdin, Connor A ; Drake, Isabel ; Natarajan, Pradeep ; Bick, Alexander G ; Cook, Nancy R ; Chasman, Daniel I ; Baber, Usman ; Mehran, Roxana ; Rader, Daniel J ; Fuster, Valentin ; Boerwinkle, Eric ; Melander, Olle ; Orho-Melander, Marju ; Ridker, Paul M ; Kathiresan, Sekar
Subjects: Aged ; Arteriosclerosis ; Calcification (ectopic) ; Cancer ; Cardiac and Cardiovascular Systems ; Cardiovascular disease ; Clinical Medicine ; Cohort Studies ; Coronary artery ; Coronary Disease - epidemiology ; Coronary Disease - genetics ; Coronary Disease - prevention & control ; Coronary vessels ; Cross-Sectional Studies ; Diet ; Female ; Genetic Predisposition to Disease ; Genetics ; Genomes ; Health risk assessment ; Healthy Lifestyle ; Heart diseases ; Humans ; Incidence ; Kardiologi ; Klinisk medicin ; Lifestyles ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Middle Aged ; Multifactorial Inheritance ; Nucleotide sequence ; Patient Compliance ; Physical activity ; Polymorphism, Genetic ; Risk ; Risk factors ; Smoking
Is Part Of: The New England journal of medicine, 2016-12, Vol.375 (24), p.2349-2358
Description: Using a polygenic score of DNA sequence polymorphisms, the authors of this study quantified genetic risk and assessed four healthy lifestyle factors. Among participants at high genetic risk, a healthy lifestyle was associated with a reduced risk of coronary disease. Both genetic and lifestyle factors are key drivers of coronary artery disease, a complex disorder that is the leading cause of death worldwide. 1 A familial pattern in the risk of coronary artery disease was first described in 1938 and was subsequently confirmed in large studies involving twins and prospective cohorts. 2 – 6 Since 2007, genomewide association analyses have identified more than 50 independent loci associated with the risk of coronary artery disease. 7 – 15 These risk alleles, when aggregated into a polygenic risk score, are predictive of incident coronary events and provide a continuous and quantitative measure of genetic susceptibility. 16 – 24 Much . . .
Publisher: United States: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa1605086
PMID: 27959714
Source: ProQuest One Psychology
AUTh Library subscriptions: ProQuest Central
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Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease

Copyright © 2016 Massachusetts Medical Society. All rights reserved. ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1605086 ;PMID: 27959714

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