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Inflammasome Complexes: Emerging Mechanisms and Effector Functions

Cell, 2016-05, Vol.165 (4), p.792-800 [Peer Reviewed Journal]

2016 Elsevier Inc. ;Copyright © 2016 Elsevier Inc. All rights reserved. ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2016.03.046 ;PMID: 27153493

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  • Title:
    Inflammasome Complexes: Emerging Mechanisms and Effector Functions
  • Author: Rathinam, Vijay A.K. ; Fitzgerald, Katherine A.
  • Subjects: Animals ; Cell Death ; Humans ; Inflammasomes - immunology ; Inflammasomes - physiology ; Inflammation - immunology ; Inflammation - metabolism ; Signal Transduction
  • Is Part Of: Cell, 2016-05, Vol.165 (4), p.792-800
  • Description: Canonical activation of the inflammasome is critical to promote caspase-1-dependent maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic cell death in response to pathogens and endogenous danger signals. Recent discoveries, however, are beginning to unveil new components of the inflammasome machinery as well as the full spectrum of inflammasome functions, extending their influence beyond canonical functions to regulation of eicosanoid storm, autophagy, and metabolism. In addition, the receptor components of the inflammasome can also regulate diverse biological processes, such as cellular proliferation, gene transcription, and tumorigenesis, all of which are independent of their inflammasome complex-forming capabilities. Here, we review these recent advances that are shaping our understanding of the complex biology of the inflammasome and its constituents. Recent discoveries are helping to unveil the complexity of the inflammasome’s biology, extending its function beyond the traditional roles in cytokine maturation and cell death to a variety of non-canonical functions, such as regulation of autophagy, metabolism, gene expression, cellular proliferation, and tumorigenesis.
  • Publisher: United States: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 0092-8674
    EISSN: 1097-4172
    DOI: 10.1016/j.cell.2016.03.046
    PMID: 27153493
  • Source: MEDLINE
    Open Access: Cell Press Free Archives
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