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Hyponatraemia and cerebral oedema due to a modafinil overdose

BMJ case reports, 2020-07, Vol.13 (7), p.e234530 [Peer Reviewed Journal]

BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ. ;2020 BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ. ;BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ. 2020 ;ISSN: 1757-790X ;EISSN: 1757-790X ;DOI: 10.1136/bcr-2020-234530 ;PMID: 32624486

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Title:
Hyponatraemia and cerebral oedema due to a modafinil overdose
Author: Kandasamy, Rohan Oliver ; Kaminskaite, Viktorija ; May, Felix
Subjects: Adult ; Antibodies ; Biochemistry ; Brain Edema - chemically induced ; Brain Edema - diagnosis ; Brain Edema - therapy ; Central Nervous System Stimulants - poisoning ; Creatinine ; Drug dosages ; Drug overdose ; Drug Overdose - complications ; Edema ; Herbal medicine ; Humans ; Hyponatremia ; Hyponatremia - chemically induced ; Hyponatremia - diagnosis ; Hyponatremia - therapy ; Male ; Modafinil - poisoning ; Nervous system ; Pneumonia ; Potassium ; Transplants & implants ; Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions ; Urine
Is Part Of: BMJ case reports, 2020-07, Vol.13 (7), p.e234530
Description: Modafinil is a non-amphetamine stimulant that is prescribed for narcolepsy-associated sleepiness as well as reported off-licence uses among university students looking to improve wakefulness and focus. There is limited information in the medical literature about supratherapeutic modafinil dosage, symptomatology and management of overdose. We report a case of a healthy 32-year-old man who was found unconscious, having vomited, with an empty modafinil blister strip. At the emergency department, he presented with reduced Glasgow Coma Scale and prolonged episodes of vomiting. This acute presentation was conservatively managed in the intensive care unit. Antibiotics were also given for a suspected aspiration pneumonia. CT of the head showed cerebral oedema and biochemistry investigations revealed hyponatraemia. Result aetiology was unclear, however, it has been theorised to be secondary to a sizeable modafinil overdose.
Publisher: England: BMJ Publishing Group LTD
Language: English
Identifier: ISSN: 1757-790X
EISSN: 1757-790X
DOI: 10.1136/bcr-2020-234530
PMID: 32624486
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
ProQuest Central

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Hyponatraemia and cerebral oedema due to a modafinil overdose

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