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Eco-friendly synthesis, characterization, in vitro and in vivo anti-inflammatory activity of silver nanoparticle-mediated Selaginella myosurus aqueous extract

International journal of nanomedicine, 2018-01, Vol.13, p.8537-8548 [Peer Reviewed Journal]

COPYRIGHT 2018 Dove Medical Press Limited ;2018. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2018 Belle Ebanda Kedi et al. This work is published and licensed by Dove Medical Press Limited 2018 ;ISSN: 1178-2013 ;ISSN: 1176-9114 ;EISSN: 1178-2013 ;DOI: 10.2147/IJN.S174530 ;PMID: 30587976

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Title:
Eco-friendly synthesis, characterization, in vitro and in vivo anti-inflammatory activity of silver nanoparticle-mediated Selaginella myosurus aqueous extract
Author: Kedi, Philippe Belle Ebanda ; Meva, Francois Eya'ane ; Kotsedi, Lebogang ; Nguemfo, Edwige Laure ; Zangueu, Calvin Bogning ; Ntoumba, Agnes Antoinette ; Mohamed, Hamza Elsayed Ahmed ; Dongmo, Alain Bertrand ; Maaza, Malik
Subjects: Albumin ; Albumins - metabolism ; Alzheimers disease ; Analysis ; Animals ; Anti-Infective Agents - pharmacology ; Anti-inflammatory ; Anti-inflammatory agents ; Anti-Inflammatory Agents - chemical synthesis ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Bioavailability ; Biological products ; Cardiovascular disease ; Carrageenan ; Cell adhesion & migration ; Diabetes ; Eco-friendly synthesis ; Edema ; Edema - drug therapy ; Edema - pathology ; Electron microscopy ; Green Chemistry Technology - methods ; Halides ; Herbal medicine ; Hydrogen-Ion Concentration ; Inflammation ; Infrared spectroscopy ; Medicinal plants ; Medicine ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - ultrastructure ; Microscopy ; Nanoparticles ; Nanotechnology ; Nitrates ; Original Research ; Pharmaceutical sciences ; Plant Extracts - chemical synthesis ; Plant Extracts - pharmacology ; Plants (Organisms) ; Powders (Particulate matter) ; Protein Denaturation ; Quality control ; Quality management ; Rats, Wistar ; Selaginella myosurus ; Selaginellaceae - chemistry ; Silver ; Silver - pharmacology ; Silver nanoparticles ; Spectrometry, X-Ray Emission ; Spectrophotometry, Ultraviolet ; Spectroscopy ; Spectroscopy, Fourier Transform Infrared ; Ultraviolet-visible spectroscopy ; X-Ray Diffraction ; X-ray spectroscopy
Is Part Of: International journal of nanomedicine, 2018-01, Vol.13, p.8537-8548
Description: There is emerging interest in medicinal plants in the biomedical field, due to their multitude of chemicals which show anti-inflammatory, antimicrobial, antiviral, or antitumoral potential. Research on medicinal plants has shown that nanotechnology could offer new solutions in the quality control, delivery aspects, or in sustaining herbal biological activities. This work reports on the preparation and characterization of silver nanoparticle-mediated plant extract. Ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, powder X-ray diffraction, energy dispersive X-ray spectroscopy, high-resolution scanning electron microscopy, high-resolution transmission electron microscopy, and selected area electron diffraction have been used to characterize the prepared silver nanoparticles. The synthetic stability was studied by varying concentrations and pH of reactants. Egg albumin denaturation and carrageenan-induced rat paw edema model were used to ascertain the anti-inflammation. Ultraviolet-visible spectroscopy gave plasmon resonance ranging between 420 and 480 nm while Fourier transform infrared spectroscopy proved nano interface functionalized with organics. The powder X-ray diffraction pattern is in agreement with silver and silver chloride nanoparticles of crystallite size 33.7 nm and 44.2 nm for silver and silver chloride, respectively. Energy dispersive X-ray spectroscopy enables elemental characterization of the particles consisting of silver and silver chloride among main elements. Spherical silver grain of 58.81 nm average size has been depicted with high-resolution scanning electron microscopy and high-resolution transmission electron microscopy. Inhibitions of 99% and 60% were obtained in vitro and in vivo, respectively. The albumin denaturation and carrageenan-induced rat hind paw edema model to assess the anti-inflammatory potential of generated nanoparticles suggests that the silver nanoparticles may act as reducing/inhibiting agents on the release of acute inflammatory mediators. Hence, this work clearly demonstrated that silver nanoparticles mediated- could be considered as a potential source for anti-inflammatory drugs.
Publisher: New Zealand: Dove Medical Press Limited
Language: English
Identifier: ISSN: 1178-2013
ISSN: 1176-9114
EISSN: 1178-2013
DOI: 10.2147/IJN.S174530
PMID: 30587976
Source: Open Access: PubMed Central
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
Directory of Open Access Journals
ProQuest Central
Dove Press Free

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Eco-friendly synthesis, characterization, in vitro and in vivo anti-inflammatory activity of silver nanoparticle-mediated Selaginella myosurus aqueous extract

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