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Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism

Oncology reports, 2017-01, Vol.37 (1), p.435-441 [Peer Reviewed Journal]

Copyright © 2016, Spandidos Publications ;COPYRIGHT 2017 Spandidos Publications ;COPYRIGHT 2017 Spandidos Publications ;ISSN: 1021-335X ;EISSN: 1791-2431 ;DOI: 10.3892/or.2016.5224 ;PMID: 27840963

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Title:
Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism
Author: Yang, Zhifan ; Li, Xiucheng ; Han, Weiqi ; Lu, Xuanyuan ; Jin, Songtao ; Yang, Wanlei ; Li, Jianlei ; He, Wei ; Qian, Yu
Subjects: Apoptosis ; Apoptosis - drug effects ; Bioflavonoids ; Bone cancer ; Bone Neoplasms - pathology ; Bone Neoplasms - prevention & control ; Care and treatment ; Caspase 3 - metabolism ; Caspase 8 - metabolism ; Cell adhesion & migration ; Cell cycle ; Cell growth ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cellular signal transduction ; Chemotherapy ; Cyclin D1 - metabolism ; Development and progression ; Flavones ; Flavonoids ; Flavonoids - pharmacology ; galangin ; Genetic aspects ; Health aspects ; Humans ; Immunoglobulins ; invasion ; Kinases ; Liver cancer ; Matrix Metalloproteinase 2 - metabolism ; Medical prognosis ; Metastasis ; Osteosarcoma ; Osteosarcoma - pathology ; Osteosarcoma - prevention & control ; Phosphatidylinositol 3-Kinases - metabolism ; PI3K ; proliferation ; Protein expression ; Proteins ; Signal Transduction - drug effects ; Software ; Studies ; Tumors ; Variance analysis
Is Part Of: Oncology reports, 2017-01, Vol.37 (1), p.435-441
Description: Osteosarcoma is the most common malignant bone tumor that frequently affects adolescents. Osteosarcoma cells tend to proliferate and invade other tissues such as those of the lungs. Currently, neoadjuvant chemotherapy is the primary strategy to prevent tumor progression. However, its adverse effects result in poor long-term outcomes. Previous research has shown that galangin exhibits antitumor properties on several types of cancer cells; however its effect on osteosarcoma cells is yet unknown. The aims of this study were to evaluate the effects of galangin on the proliferation, apoptosis, migration, and invasion of osteosarcoma cells and to explore the underlying mechanisms. We found that the proliferation of MG63 and U20S osteosarcoma cells decreased significantly, while the apoptosis of MG63 cells accelerated significantly after exposure to galangin. In addition, the migration and invasion of MG63 cells were significantly inhibited by galangin. Moreover, phosphoinositide 3-kinase (PI3K) and Aktp-Thr308 expression levels were found to be significantly lower in galangin-treated MG63 cells than in the control cells, and the protein expression levels of their downstream regulators cyclin D1 and matrix metalloproteinase 2/9 were also downregulated in galangin-treated groups, while those of p27Kip1, caspase-3, and caspase-8 were upregulated. These findings suggest that galangin suppresses osteosarcoma cells by inhibiting their proliferation and invasion and accelerating their apoptosis, and the mechanism may be associated with the inhibition of PI3K and its downstream signaling pathway.
Publisher: Greece: D.A. Spandidos
Language: English
Identifier: ISSN: 1021-335X
EISSN: 1791-2431
DOI: 10.3892/or.2016.5224
PMID: 27840963
Source: GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism

Copyright © 2016, Spandidos Publications ;COPYRIGHT 2017 Spandidos Publications ;COPYRIGHT 2017 Spandidos Publications ;ISSN: 1021-335X ;EISSN: 1791-2431 ;DOI: 10.3892/or.2016.5224 ;PMID: 27840963

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