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Chemokines and cytokines network in the pathogenesis of the inflammatory skin diseases: atopic dermatitis, psoriasis and skin mastocytosis

Postȩpy dermatologii i alergologii, 2014-01, Vol.31 (2), p.84-91 [Peer Reviewed Journal]

Copyright Termedia Publishing House 2014 ;Copyright © 2014 Termedia 2014 ;ISSN: 1642-395X ;EISSN: 2299-0046 ;DOI: 10.5114/pdia.2014.40920 ;PMID: 25097473

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  • Title:
    Chemokines and cytokines network in the pathogenesis of the inflammatory skin diseases: atopic dermatitis, psoriasis and skin mastocytosis
  • Author: Nedoszytko, Bogusław ; Sokołowska-Wojdyło, Małgorzata ; Ruckemann-Dziurdzińska, Katarzyna ; Roszkiewicz, Jadwiga ; Nowicki, Roman J
  • Subjects: Review Paper
  • Is Part Of: Postȩpy dermatologii i alergologii, 2014-01, Vol.31 (2), p.84-91
  • Description: Chemokines are signaling peptides which regulate cell trafficking and provide control of the tissue-specific cell homing. In the skin, chemokines are secreted both by the resident cells such as keratinocytes, melanocytes, fibroblasts, dendritic cells and mast cells, as well as by infiltrated cells - lymphocytes, eosinophils, and monocytes. Chemokines, together with cytokines, participate in induction and maintenance of inflammation in the skin and regulate the composition of the cellular infiltrates. Inflammation within the skin is a feature shared by atopic dermatitis and psoriasis, two of the most common dermatoses. Accumulation of activated mast cells in the affected skin is seen both in atopic dermatitis and in psoriasis. This paper presents a concise overview of the current knowledge on the role chemokines have in pathogenesis of atopic dermatitis, psoriasis, and mastocytosis, a disease caused directly by the accumulation and activation of mast cells in the skin.
  • Publisher: Poland: Termedia Publishing House
  • Language: English;Polish
  • Identifier: ISSN: 1642-395X
    EISSN: 2299-0046
    DOI: 10.5114/pdia.2014.40920
    PMID: 25097473
  • Source: DOAJ Directory of Open Access Journals
    PubMed Central
    ProQuest Central
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