Language:

Clinicoplacental phenotypes vary with gestational age: an analysis by classical and clustering methods

Acta obstetricia et gynecologica Scandinavica, 2014-04, Vol.93 (4), p.392-398 [Peer Reviewed Journal]

2014 Nordic Federation of Societies of Obstetrics and Gynecology ;2014 Nordic Federation of Societies of Obstetrics and Gynecology. ;ISSN: 0001-6349 ;EISSN: 1600-0412 ;DOI: 10.1111/aogs.12350 ;PMID: 24506140 ;CODEN: AOGSAE

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Clinicoplacental phenotypes vary with gestational age: an analysis by classical and clustering methods
Author: Stanek, Jerzy ; Biesiada, Jacek ; Trzeszcz, Martyna
Subjects: Abruptio Placentae - diagnosis ; Adult ; Cluster Analysis ; Databases, Factual ; Female ; Fetal Growth Retardation - etiology ; Fetal Membranes, Premature Rupture - diagnosis ; Gestational Age ; high-risk pregnancy ; Humans ; Meconium ; Phenotype ; placenta ; Placenta - pathology ; Placenta - physiopathology ; Placenta Diseases - diagnosis ; Placenta Diseases - pathology ; Placenta Diseases - physiopathology ; Pre-Eclampsia - diagnosis ; Pregnancy ; pregnancy complications ; Pregnancy Complications - diagnosis ; Pregnancy Complications - pathology ; Pregnancy Complications - physiopathology ; Pregnancy in Diabetics - diagnosis ; Pregnancy Trimester, Second ; Pregnancy Trimester, Third ; Retrospective Studies ; stillbirth ; Substance-Related Disorders - complications
Is Part Of: Acta obstetricia et gynecologica Scandinavica, 2014-04, Vol.93 (4), p.392-398
Description: Objective As the patterns and frequency of maternal and clinical conditions and outcomes and gross and histological placental features and lesions vary with gestational age at delivery, we aimed to study the impact of these changes on the placental diagnosis, hoping to uncover potential novel clusters of gestational age‐associated clinical and pathological diagnoses. Design Retrospective statistical analysis of clinicoplacental database. Population We analyzed 28 clinical (maternal and fetal) and 49 gross and microscopic placental variables from 3294 consecutively signed placentas received between 2001 and 2012, divided into three gestational age groups: 16–27 weeks, 697 cases; 28–36 weeks, 1365 cases; and 37+ weeks, in all 1232 cases. Methods Classical statistics by chi‐squared and Fischer's tests, and the Ward agglomerative hierarchical clustering and multidimensional scaling techniques, were used. Results The placental phenotypes clustered statistically significantly with severe preeclampsia in the second trimester; preterm premature rupture of membranes, placental abruption, and fetal growth restriction in the whole third trimester; and abnormally invasive placenta, thick meconium, maternal diabetes mellitus, and substance abuse in term pregnancies. Conclusions The applied statistical analyses made it possible to simultaneously compare the strength of clinicoplacental associations separately in three pregnancy intervals. Placental clinicopathological associations are strongest for the second trimester, i.e. severe preeclampsia and preterm ascending infection‐related conditions, but were not significant for other pregnancy complications such as mild preeclampsia, chronic hypertension, diabetes mellitus, or umbilical cord compromise.
Publisher: United States: Blackwell Publishing Ltd
Language: English;French;German
Identifier: ISSN: 0001-6349
EISSN: 1600-0412
DOI: 10.1111/aogs.12350
PMID: 24506140
CODEN: AOGSAE
Source: Journals@Ovid Open Access Journal Collection Rolling
MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Clinicoplacental phenotypes vary with gestational age: an analysis by classical and clustering methods

2014 Nordic Federation of Societies of Obstetrics and Gynecology ;2014 Nordic Federation of Societies of Obstetrics and Gynecology. ;ISSN: 0001-6349 ;EISSN: 1600-0412 ;DOI: 10.1111/aogs.12350 ;PMID: 24506140 ;CODEN: AOGSAE

Searching Remote Databases, Please Wait