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Angiogenic biomarkers in pregnancy: defining maternal and fetal health

Acta obstetricia et gynecologica Scandinavica, 2015-08, Vol.94 (8), p.820-832 [Peer Reviewed Journal]

2015 Nordic Federation of Societies of Obstetrics and Gynecology ;2015 Nordic Federation of Societies of Obstetrics and Gynecology. ;Acta Obstetricia et Gynecologica Scandinavica © 2015 Nordic Federation of Societies of Obstetrics and Gynecology ;info:eu-repo/semantics/openAccess ;ISSN: 0001-6349 ;EISSN: 1600-0412 ;DOI: 10.1111/aogs.12629 ;PMID: 25753566 ;CODEN: AOGSAE

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Title:
Angiogenic biomarkers in pregnancy: defining maternal and fetal health
Author: Rasmussen, Lene G. ; Lykke, Jacob A. ; Staff, Anne C.
Subjects: angiogenic factors ; Antigens, CD - blood ; Biomarkers - blood ; Breast cancer ; Cardiovascular disease ; Diabetes ; Endoglin ; Female ; Fetal Growth Retardation - blood ; Growth factors ; Health risk assessment ; high-risk pregnancies ; Humans ; Hypertension ; Kinases ; maternal morbidity ; maternal mortality ; molecular biology ; Placenta Growth Factor ; Pre-Eclampsia - blood ; Predictive Value of Tests ; Preeclampsia ; Pregnancy ; Pregnancy Proteins - blood ; Proteins ; Receptors, Cell Surface - blood ; Vascular Endothelial Growth Factor Receptor-1 - blood ; women's health
Is Part Of: Acta obstetricia et gynecologica Scandinavica, 2015-08, Vol.94 (8), p.820-832
Description: We review diagnostic and predictive roles of the angiogenic proteins placental growth factor, soluble fms‐like tyrosine kinase 1, and soluble endoglin in preeclampsia, and their association with future cardiovascular disease, diabetes, and breast cancer. Specific patterns of these proteins represent preeclamptic prediction markers and combined with maternal and clinical characteristics, the predictive values increase. Women experiencing preeclampsia have increased risks of developing cardiovascular diseases and diabetes, and a decreased risk of breast cancer. High placental growth factor concentrations have, in elderly patients, been shown to predict cardiovascular events. Diabetes is also a risk factor for future cardiovascular disease. Diabetic vascular complications are associated with increased soluble endoglin concentrations, and vascular endothelial growth factor concentrations are correlated to HbA1c and fasting glucose. Hence dysregulation in angiogenic proteins may link preeclampsia and cardiovascular diseases, targeting women who could in future benefit from prophylactic programs to possibly prevent, delay or reduce cardiovascular disease.
Publisher: United States: Blackwell Publishing Ltd
Language: English;French;German;Norwegian
Identifier: ISSN: 0001-6349
EISSN: 1600-0412
DOI: 10.1111/aogs.12629
PMID: 25753566
CODEN: AOGSAE
Source: Journals@Ovid Open Access Journal Collection Rolling
MEDLINE
NORA Norwegian Open Research Archives
Alma/SFX Local Collection

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Angiogenic biomarkers in pregnancy: defining maternal and fetal health

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