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Galectin-3 in Cardiovascular Diseases

International journal of molecular sciences, 2020-12, Vol.21 (23), p.9232 [Peer Reviewed Journal]

2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2020 by the authors. 2020 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms21239232 ;PMID: 33287402

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Title:
Galectin-3 in Cardiovascular Diseases
Author: Blanda, Valeria ; Bracale, Umberto Marcello ; Di Taranto, Maria Donata ; Fortunato, Giuliana
Subjects: Angiogenesis ; Animals ; Apoptosis ; Arteriosclerosis ; Atherosclerosis ; Autophagy ; biomarker ; Biomarkers ; Blood Proteins - antagonists & inhibitors ; Blood Proteins - genetics ; Blood Proteins - metabolism ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - drug therapy ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - metabolism ; Cardiovascular Diseases - physiopathology ; Cell adhesion ; Cell adhesion & migration ; Cell cycle ; Collagen ; Congestive heart failure ; Diagnostic software ; Diagnostic systems ; Disease Models, Animal ; Disease Susceptibility ; Extracellular matrix ; Fibrillation ; Fibrosis ; Galactosides ; Galectin-3 ; Galectins - antagonists & inhibitors ; Galectins - genetics ; Galectins - metabolism ; Heart attacks ; Heart Failure ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Inflammation ; Inflammation - complications ; Inflammation - etiology ; Inflammation - metabolism ; Kinases ; Ligands ; Molecular modelling ; Molecular Targeted Therapy ; Morbidity ; Mortality ; Myocardium ; Pathogenesis ; Proteins ; Review
Is Part Of: International journal of molecular sciences, 2020-12, Vol.21 (23), p.9232
Description: Galectin-3 (Gal-3) is a β-galactoside-binding protein belonging to the lectin family with pleiotropic regulatory activities and several physiological cellular functions, such as cellular growth, proliferation, apoptosis, differentiation, cellular adhesion, and tissue repair. Inflammation, tissue fibrosis and angiogenesis are the main processes in which Gal-3 is involved. It is implicated in the pathogenesis of several diseases, including organ fibrosis, chronic inflammation, cancer, atherosclerosis and other cardiovascular diseases (CVDs). This review aims to explore the connections of Gal-3 with cardiovascular diseases since they represent a major cause of morbidity and mortality. We herein discuss the evidence on the pro-inflammatory role of Gal-3 in the atherogenic process as well as the association with plaque features linked to lesion stability. We report the biological role and molecular mechanisms of Gal-3 in other CVDs, highlighting its involvement in the development of cardiac fibrosis and impaired myocardium remodelling, resulting in heart failure and atrial fibrillation. The role of Gal-3 as a prognostic marker of heart failure is described together with possible diagnostic applications to other CVDs. Finally, we report the tentative use of Gal-3 inhibition as a therapeutic approach to prevent cardiac inflammation and fibrosis.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 1422-0067
ISSN: 1661-6596
EISSN: 1422-0067
DOI: 10.3390/ijms21239232
PMID: 33287402
Source: DOAJ Directory of Open Access Journals
MEDLINE
PubMed Central
ProQuest Central

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Galectin-3 in Cardiovascular Diseases

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