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Comparison between 0.1% Nepafenac and 1% Prednisolone Eye Drop in Postoperative Management Following Micro-incisional Cataract Surgery

Korean Journal of Ophthalmology, 2021, 35(3), , pp.188-197 [Peer Reviewed Journal]

2021 The Korean Ophthalmological Society 2021 ;ISSN: 1011-8942 ;EISSN: 2092-9382 ;DOI: 10.3341/kjo.2020.0135 ;PMID: 34120417

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  • Title:
    Comparison between 0.1% Nepafenac and 1% Prednisolone Eye Drop in Postoperative Management Following Micro-incisional Cataract Surgery
  • Author: Sarkar, Sandip ; Bardoloi, Narayan ; Deb, Amit Kumar
  • Subjects: Original ; 안과학
  • Is Part Of: Korean Journal of Ophthalmology, 2021, 35(3), , pp.188-197
  • Description: PURPOSETo compare the efficacy of 0.1% nepafenac and 1% prednisolone acetate eye drop in postoperative inflammation control in micro-incisional cataract surgery. METHODSWe conducted a prospective, randomized, comparative, single-blind study. All the patients underwent temporal 2.2-mm micro-incisional cataract surgery. They were randomized into two groups (group A and B). Group A received 0.1% nepafenac eye drops 4 times/day for 4 weeks and group B received 1% prednisolone acetate eye drops in tapering doses for 4 weeks after surgery. Both the groups received moxifloxacin 0.5% eye drops 4 times/day for 2 weeks. Patients were examined on 1st, 7th, and 30th postoperative days and parameters of postoperative inflammation were evaluated and noted at each visit. RESULTSA total of 200 patients were enrolled in the study. However, five patients lost to follow up, group A had 97 and group B had 98 patients respectively. Results were statistically insignificant in terms of the difference in lid edema, conjunctival congestion, corneal edema, anterior chamber cells and flare between the two groups with p-values >0.05 for each parameter at each visit. However, the difference in mean central macular thickness between the groups was significant (205.713 ± 17.14 vs. 220.984 ± 32.83 in group A and B, respectively, p ≤ 0.001) at 1 month. Also, the mean pain score was significantly lower (p = 0.018) in the nepafenac group at day 7 of surgery. CONCLUSIONSNepafenac is equally effective and non-inferior to prednisolone acetate in suppression and prevention of inflammation in postoperative period.
  • Publisher: Korean Ophthalmological Society
  • Language: English
  • Identifier: ISSN: 1011-8942
    EISSN: 2092-9382
    DOI: 10.3341/kjo.2020.0135
    PMID: 34120417
  • Source: KoreaMed Synapse
    PubMed Central
    KoreaMed Open Access
    DOAJ Directory of Open Access Journals
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