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Cytokines as therapeutic targets for cardio- and cerebrovascular diseases

Basic research in cardiology, 2021-12, Vol.116 (1), p.23-23, Article 23 [Peer Reviewed Journal]

The Author(s) 2021 ;COPYRIGHT 2021 Springer ;The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 0300-8428 ;EISSN: 1435-1803 ;DOI: 10.1007/s00395-021-00863-x ;PMID: 33770265

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Title:
Cytokines as therapeutic targets for cardio- and cerebrovascular diseases
Author: Liberale, Luca ; Ministrini, Stefano ; Carbone, Federico ; Camici, Giovanni G. ; Montecucco, Fabrizio
Subjects: Animals ; Anti-Inflammatory Agents - adverse effects ; Anti-Inflammatory Agents - therapeutic use ; Arteriosclerosis ; Atherosclerosis ; Cardiology ; Cardiovascular Diseases - drug therapy ; Cardiovascular Diseases - immunology ; Cardiovascular Diseases - metabolism ; Cardiovascular Diseases - physiopathology ; Cardiovascular System - drug effects ; Cardiovascular System - immunology ; Cardiovascular System - metabolism ; Cardiovascular System - physiopathology ; Cerebral infarction ; Cerebrovascular diseases ; Cerebrovascular Disorders - drug therapy ; Cerebrovascular Disorders - immunology ; Cerebrovascular Disorders - metabolism ; Cerebrovascular Disorders - physiopathology ; Clinical trials ; Complications ; Crosstalk ; Cytokines ; Cytokines - antagonists & inhibitors ; Cytokines - metabolism ; Health aspects ; Humans ; Inflammation ; Inflammation - drug therapy ; Inflammation - immunology ; Inflammation - metabolism ; Inflammation - physiopathology ; Inflammation Mediators - antagonists & inhibitors ; Inflammation Mediators - metabolism ; Interleukins ; Intracellular signalling ; Ischemia ; Medicine ; Medicine & Public Health ; Modulation ; Molecular Targeted Therapy ; Morbidity ; Myocardial infarction ; Prevention ; Review ; Side effects ; Signal Transduction ; Therapeutic applications ; Therapeutic targets ; Transcription activation ; Transcription factors ; Vascular diseases
Is Part Of: Basic research in cardiology, 2021-12, Vol.116 (1), p.23-23, Article 23
Description: Despite major advances in prevention and treatment, cardiac and cerebral atherothrombotic complications still account for substantial morbidity and mortality worldwide. In this context, inflammation is involved in the chronic process leading atherosclerotic plaque formation and its complications, as well as in the maladaptive response to acute ischemic events. For this reason, modulation of inflammation is nowadays seen as a promising therapeutic strategy to counteract the burden of cardio- and cerebrovascular disease. Being produced and recognized by both inflammatory and vascular cells, the complex network of cytokines holds key functions in the crosstalk of these two systems and orchestrates the progression of atherothrombosis. By binding to membrane receptors, these soluble mediators trigger specific intracellular signaling pathways eventually leading to the activation of transcription factors and a deep modulation of cell function. Both stimulatory and inhibitory cytokines have been described and progressively reported as markers of disease or interesting therapeutic targets in the cardiovascular field. Nevertheless, cytokine inhibition is burdened by harmful side effects that will most likely prevent its chronic use in favor of acute administrations in well-selected subjects at high risk. Here, we summarize the current state of knowledge regarding the modulatory role of cytokines on atherosclerosis, myocardial infarction, and stroke. Then, we discuss evidence from clinical trials specifically targeting cytokines and the potential implication of these advances into daily clinical practice.
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
Language: English
Identifier: ISSN: 0300-8428
EISSN: 1435-1803
DOI: 10.1007/s00395-021-00863-x
PMID: 33770265
Source: MEDLINE
Springer OA刊
ProQuest Central

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Cytokines as therapeutic targets for cardio- and cerebrovascular diseases

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