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Hypophagia induced by salmon calcitonin, but not by amylin, is partially driven by malaise and is mediated by CGRP neurons

Molecular metabolism (Germany), 2022-04, Vol.58, p.101444-101444, Article 101444 [Peer Reviewed Journal]

2022 The Author(s) ;Copyright © 2022 The Author(s). Published by Elsevier GmbH.. All rights reserved. ;2022 The Author(s) 2022 ;ISSN: 2212-8778 ;EISSN: 2212-8778 ;DOI: 10.1016/j.molmet.2022.101444 ;PMID: 35091058

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  • Title:
    Hypophagia induced by salmon calcitonin, but not by amylin, is partially driven by malaise and is mediated by CGRP neurons
  • Author: Boccia, Lavinia ; Borner, Tito ; Ghidewon, Misgana Y. ; Kulka, Patricia ; Piffaretti, Chiara ; Doebley, Sarah A. ; De Jonghe, Bart C. ; Grill, Harvey J. ; Lutz, Thomas A. ; Le Foll, Christelle
  • Subjects: Animals ; Anorexia - chemically induced ; Appetite Depressants - adverse effects ; Appetite Depressants - metabolism ; Aversion ; Calcitonin ; Calcitonin Gene-Related Peptide - metabolism ; Calcitonin gene-related peptides neurons ; Emesis ; Hindbrain ; Islet Amyloid Polypeptide - metabolism ; Lateral parabrachial nucleus ; Mice ; Nausea - metabolism ; Neurons - metabolism ; Original ; Rats ; Suncus murinus ; Vomiting
  • Is Part Of: Molecular metabolism (Germany), 2022-04, Vol.58, p.101444-101444, Article 101444
  • Description: The behavioral mechanisms and the neuronal pathways mediated by amylin and its long-acting analog sCT (salmon calcitonin) are not fully understood and it is unclear to what extent sCT and amylin engage overlapping or distinct neuronal subpopulations to reduce food intake. We here hypothesize that amylin and sCT recruit different neuronal population to mediate their anorectic effects. Viral approaches were used to inhibit calcitonin gene-related peptide (CGRP) lateral parabrachial nucleus (LPBN) neurons and assess their role in amylin’s and sCT’s ability to decrease food intake in mice. In addition, to test the involvement of LPBN CGRP neuropeptidergic signaling in the mediation of amylin and sCT’s effects, a LPBN site-specific knockdown was performed in rats. To deeper investigate whether the greater anorectic effect of sCT compared to amylin is due do the recruitment of additional neuronal pathways related to malaise multiple and distinct animal models tested whether amylin and sCT induce conditioned avoidance, nausea, emesis, and conditioned affective taste aversion. Our results indicate that permanent or transient inhibition of CGRP neurons in LPBN blunts sCT-, but not amylin-induced anorexia and neuronal activation. Importantly, sCT but not amylin induces behaviors indicative of malaise including conditioned affective aversion, nausea, emesis, and conditioned avoidance; the latter mediated by CGRPLPBN neurons. Together, the present study highlights that although amylin and sCT comparably decrease food intake, sCT is distinctive from amylin in the activation of anorectic neuronal pathways associated with malaise. •CGRP neurons mediate the effect of the amylin agonist salmon calcitonin (sCT) on food intake.•Amylin's hypophagic effect does not require CGRP neurons.•sCT-induced anorexia but not amylin is associated with malaise.
  • Publisher: Germany: Elsevier GmbH
  • Language: English
  • Identifier: ISSN: 2212-8778
    EISSN: 2212-8778
    DOI: 10.1016/j.molmet.2022.101444
    PMID: 35091058
  • Source: MEDLINE
    PubMed Central
    DOAJ Directory of Open Access Journals
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